Genes upregulated in a metastasizing human colon carcinoma cell line

Véronique Orian-Rousseau, Sigrun Mink, Jörg Mengwasser, Harm HogenEsch, Feng Guo, Wolf Gerolf Thies, Martin Hofmann, Peter Herrlich, Helmut Ponta

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Differential gene expression between the metastatic human colon cancer cell line HT29p and its nonmetastatic counterpart HT29-MTX was revealed by suppression subtractive hybridization. Fifty-eight individual genes showed increased mRNA levels in HT29p cells. Only 15 of these genes had been related to transformation in previous studies; the majority of genes are new candidates encoding proteins relevant for the metastatic process. Cancer profiling arrays as well as in situ hybridization study revealed that at least some of the genes obtained in the SSH screen are also differentially expressed in human tumors.

Original languageEnglish (US)
Pages (from-to)699-705
Number of pages7
JournalInternational Journal of Cancer
Volume113
Issue number5
DOIs
StatePublished - Feb 20 2005
Externally publishedYes

Keywords

  • Metastasis specific genes
  • Suppression subtractive hybridization

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Orian-Rousseau, V., Mink, S., Mengwasser, J., HogenEsch, H., Guo, F., Thies, W. G., Hofmann, M., Herrlich, P., & Ponta, H. (2005). Genes upregulated in a metastasizing human colon carcinoma cell line. International Journal of Cancer, 113(5), 699-705. https://doi.org/10.1002/ijc.20644