Genetic and environmental modifiers of Alzheimer's disease phenotypes in the mouse

Davis Ryman, Bruce Lamb

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

As a group, strains of laboratory mice carrying Alzheimer's disease (AD)-related transgenes are currently the most widely studied animal models of AD. Many AD mouse models carrying the same or similar transgene constructs demonstrate strikingly different phenotypic responses to transgene expression, mimicking the apparent genetic complexity of AD pathogenesis seen in the human population. Genetic differences between the numerous mouse model strains used for AD research can significantly affect correct interpretation and cross-comparison of experimental findings, making genetic background an important consideration for all work in mouse models of AD. Furthermore, because of the potential for discovering novel genetic modifiers of AD pathogenesis, the effects of genetic background on AD phenotypes in the mouse can prove a worthwhile subject of study in their own right. This review discusses the implications of genetic modifiers for mouse and human AD research, and summarizes recent findings identifying significant roles for genetic background in modifying important phenotypes in AD mouse models, including premature death, amyloid deposition, tau hyperphosphorylation, and responsiveness to environmental or treatment interventions.

Original languageEnglish (US)
Pages (from-to)465-473
Number of pages9
JournalCurrent Alzheimer Research
Volume3
Issue number5
DOIs
StatePublished - Dec 2006
Externally publishedYes

Fingerprint

Alzheimer Disease
Phenotype
Transgenes
Premature Mortality
Research
Amyloid
Animal Models
Population
Genetic Background

ASJC Scopus subject areas

  • Biological Psychiatry
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Genetic and environmental modifiers of Alzheimer's disease phenotypes in the mouse. / Ryman, Davis; Lamb, Bruce.

In: Current Alzheimer Research, Vol. 3, No. 5, 12.2006, p. 465-473.

Research output: Contribution to journalArticle

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