Genetic association of bipolar disorder with the β3 nicotinic receptor subunit gene

Sarah M. Hartz, Peng Lin, Howard J. Edenberg, Xiaoling Xuei, Nanette Rochberg, Scott Saccone, Wade Berrettini, Elliot Nelson, John Nurnberger, Laura J. Bierut, John P. Rice, Marvin J. Miller, Elizabeth S. Bowman, N. Leela Rau, P. Ryan Moe, Nalini Samavedy, Rif El-Mallakh, Husseini Manji, Debra A. Glitz, Eric T. MeyerCarrie Smiley, Tatiana Foroud, Leah Flury, Danielle M. Dick, Theodore Reich, Allison Goate, Melvin McInnis, J. Raymond DePaulo, Dean F. MacKinnon, Francis M. Mondimore, James B. Potash, Peter P. Zandi, Dimitrios Avramopoulos, Jennifer Payne, William Byerley, Sophia Vinogradov, William Coryell, Raymond Crowe, Elliot Gershon, Judith Badner, Francis McMahon, Chunyu Liu, Alan Sanders, Maria Caserta, Steven Dinwiddie, Tu Nguyen, Donna Harakal, John Kelsoe, Rebecca McKinney, William Scheftner, Howard M. Kravitz, Diana Marta, Annette Vaughn-Brown, Laurie Bederow, Francis J. McMahon, Layla Kassem, Sevilla Detera-Wadleigh, Lisa Austin, Dennis L. Murphy, William B. Lawson, Evarista Nwulia, Maria Hipolito

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

OBJECTIVE: Owing to the clinical relationship between bipolar disorder and nicotine dependence, we investigated two research questions: (i) are genetic associations with nicotine dependence different in individuals with bipolar disorder as compared with individuals without bipolar disorder, and (ii) do loci earlier associated with nicotine dependence have pleiotropic effects on these two diseases. METHOD: Our study consisted of 916 cases with bipolar disorder and 1028 controls. On the basis of known associations with nicotine dependence, we genotyped eight single-nucleotide polymorphisms (SNPs) on chromosome 8 (three bins) in the regions of CHRNB3 and CHRNA6, and six SNPs on chromosome 15 (three bins) in the regions of CHRNA5 and CHRNA3. RESULTS: To determine whether the genetic associations with nicotine dependence are different in bipolar disorder than in the general population, we compared allele frequencies of candidate SNPs between individuals with nicotine dependence only and individuals with both nicotine dependence and bipolar disorder. There were no statistical differences between these frequencies, indicating that genetic association with nicotine dependence is similar in individuals with bipolar disorder as in the general population. In the investigation of pleiotropic effects of these SNPs on bipolar disorder, two highly correlated synonymous SNPs in CHRNB3, rs4952 and rs4953, were significantly associated with bipolar disorder (odds ratio 1.7, 95% confidence interval: 1.2-2.4, P=0.001). This association remained significant both after adjusting for a smoking covariate and analyzing the association in nonsmokers only. CONCLUSION: Our results suggest that (i) bipolar disorder does not modify the association between nicotine dependence and nicotinic receptor subunit genes, and (ii) variants in CHRNB3/CHRNA6 are independently associated with bipolar disorder.

Original languageEnglish (US)
Pages (from-to)77-84
Number of pages8
JournalPsychiatric genetics
Volume21
Issue number2
DOIs
StatePublished - Apr 2011

Keywords

  • analyses
  • CHRNA3
  • CHRNA5
  • CHRNA6
  • genetic association
  • nicotine
  • tobacco use disorder

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Genetics
  • Biological Psychiatry

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