Genetic changes associated with primary Merkel cell carcinoma

Alexander Vortmeyer, Maria J. Merino, Roland Böni, Lance A. Liotta, Andrea Cavazzana, Zhengping Zhuang

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Merkel cell carcinoma (MCC) is a malignant tumor of the skin with a well-established neuroendocrine phenotype but an unknown histogenetic origin. Cytogenetic and molecular studies have shown evidence for genetic changes on the distal portion of chromosome 1p in different tumors with well-established neuroendocrine origins, specifically neuroblastomas, malignant melanomas, and pheochromocytomas. Involvement of chromosome 1 in MCC recently has been demonstrated by cytogenetic analysis and analysis of loss of heterozygosity (LOH) in metastatic tumor tissue. We performed analysis of LOH of the distal portion of chromosome 1p in paraffin material of 10 primary MCCs after tissue microdissection, using the polymorphic markers D1S160, D1S243, D1S468, D1S1646, and D1S1598. Seven of 10 analyzed MCCs shared a distal deletion involving 1p35-36. None of the cases showed 1p involvement proximal to 1p35. The findings are similar to those described for malignant melanoma, pheochromocytoma, and neuroblastoma, tumors known to originate from neural crest cells. In conjunction with previous cytogenetic data, we conclude that Merkel cell carcinogenesis shares pathogenetic mechanisms with other neoplasms of neural crest derivation.

Original languageEnglish (US)
Pages (from-to)565-570
Number of pages6
JournalAmerican Journal of Clinical Pathology
Volume109
Issue number5
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

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Merkel Cell Carcinoma
Neural Crest
Loss of Heterozygosity
Pheochromocytoma
Neoplasms
Neuroblastoma
Cytogenetics
Melanoma
Chromosomes
Merkel Cells
Microdissection
Chromosomes, Human, Pair 1
Cytogenetic Analysis
Paraffin
Carcinogenesis
Phenotype
Skin

Keywords

  • Chromosome 1
  • Loss of heterozygosity
  • Merkel cell carcinoma
  • Microdissection

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Vortmeyer, A., Merino, M. J., Böni, R., Liotta, L. A., Cavazzana, A., & Zhuang, Z. (1998). Genetic changes associated with primary Merkel cell carcinoma. American Journal of Clinical Pathology, 109(5), 565-570. https://doi.org/10.1093/ajcp/109.5.565

Genetic changes associated with primary Merkel cell carcinoma. / Vortmeyer, Alexander; Merino, Maria J.; Böni, Roland; Liotta, Lance A.; Cavazzana, Andrea; Zhuang, Zhengping.

In: American Journal of Clinical Pathology, Vol. 109, No. 5, 01.01.1998, p. 565-570.

Research output: Contribution to journalArticle

Vortmeyer, A, Merino, MJ, Böni, R, Liotta, LA, Cavazzana, A & Zhuang, Z 1998, 'Genetic changes associated with primary Merkel cell carcinoma', American Journal of Clinical Pathology, vol. 109, no. 5, pp. 565-570. https://doi.org/10.1093/ajcp/109.5.565
Vortmeyer, Alexander ; Merino, Maria J. ; Böni, Roland ; Liotta, Lance A. ; Cavazzana, Andrea ; Zhuang, Zhengping. / Genetic changes associated with primary Merkel cell carcinoma. In: American Journal of Clinical Pathology. 1998 ; Vol. 109, No. 5. pp. 565-570.
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