Genetic clustering on the hippocampal surface for genome-wide association studies.

Derrek P. Hibar, Sarah E. Medland, Jason L. Stein, Sungeun Kim, Li Shen, Andrew Saykin, Greig I. de Zubicaray, Katie L. McMahon, Grant W. Montgomery, Nicholas G. Martin, Margaret J. Wright, Srdjan Djurovic, Ingrid A. Agartz, Ole A. Andreassen, Paul M. Thompson

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Citations (Scopus)

Abstract

Imaging genetics aims to discover how variants in the human genome influence brain measures derived from images. Genome-wide association scans (GWAS) can screen the genome for common differences in our DNA that relate to brain measures. In small samples, GWAS has low power as individual gene effects are weak and one must also correct for multiple comparisons across the genome and the image. Here we extend recent work on genetic clustering of images, to analyze surface-based models of anatomy using GWAS. We performed spherical harmonic analysis of hippocampal surfaces, automatically extracted from brain MRI scans of 1254 subjects. We clustered hippocampal surface regions with common genetic influences by examining genetic correlations (r(g)) between the normalized deformation values at all pairs of surface points. Using genetic correlations to cluster surface measures, we were able to boost effect sizes for genetic associations, compared to clustering with traditional phenotypic correlations using Pearson's r.

Original languageEnglish
Title of host publicationMedical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
Pages690-697
Number of pages8
Volume16
EditionPt 2
StatePublished - 2013

Fingerprint

Genome-Wide Association Study
Cluster Analysis
Brain
Genome
Human Genome
Anatomy
Magnetic Resonance Imaging
DNA
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hibar, D. P., Medland, S. E., Stein, J. L., Kim, S., Shen, L., Saykin, A., ... Thompson, P. M. (2013). Genetic clustering on the hippocampal surface for genome-wide association studies. In Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention (Pt 2 ed., Vol. 16, pp. 690-697)

Genetic clustering on the hippocampal surface for genome-wide association studies. / Hibar, Derrek P.; Medland, Sarah E.; Stein, Jason L.; Kim, Sungeun; Shen, Li; Saykin, Andrew; de Zubicaray, Greig I.; McMahon, Katie L.; Montgomery, Grant W.; Martin, Nicholas G.; Wright, Margaret J.; Djurovic, Srdjan; Agartz, Ingrid A.; Andreassen, Ole A.; Thompson, Paul M.

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Vol. 16 Pt 2. ed. 2013. p. 690-697.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hibar, DP, Medland, SE, Stein, JL, Kim, S, Shen, L, Saykin, A, de Zubicaray, GI, McMahon, KL, Montgomery, GW, Martin, NG, Wright, MJ, Djurovic, S, Agartz, IA, Andreassen, OA & Thompson, PM 2013, Genetic clustering on the hippocampal surface for genome-wide association studies. in Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Pt 2 edn, vol. 16, pp. 690-697.
Hibar DP, Medland SE, Stein JL, Kim S, Shen L, Saykin A et al. Genetic clustering on the hippocampal surface for genome-wide association studies. In Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Pt 2 ed. Vol. 16. 2013. p. 690-697
Hibar, Derrek P. ; Medland, Sarah E. ; Stein, Jason L. ; Kim, Sungeun ; Shen, Li ; Saykin, Andrew ; de Zubicaray, Greig I. ; McMahon, Katie L. ; Montgomery, Grant W. ; Martin, Nicholas G. ; Wright, Margaret J. ; Djurovic, Srdjan ; Agartz, Ingrid A. ; Andreassen, Ole A. ; Thompson, Paul M. / Genetic clustering on the hippocampal surface for genome-wide association studies. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Vol. 16 Pt 2. ed. 2013. pp. 690-697
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AU - Saykin, Andrew

AU - de Zubicaray, Greig I.

AU - McMahon, Katie L.

AU - Montgomery, Grant W.

AU - Martin, Nicholas G.

AU - Wright, Margaret J.

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