Genetic control of liver alcohol dehydrogenase expression in inbred mice.

L. S. Patterson, K. Zhang, Howard Edenberg, W. F. Bosron

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The expression of the mouse Adh-1 gene which encodes the ADH-AA isoenzyme of liver alcohol dehydrogenase is under genetic control. The content of alcohol dehydrogenase in the C57BL inbred strain of mice is about twice that in DBA mice. In order to examine the mechanism for control of liver alcohol dehydrogenase expression in mice, we have isolated liver RNA from high and low enzyme activity strains and quantified the content of ADH mRNA with the ADH-A cDNA that was recently cloned in our laboratory. The content of ADH-A mRNA in liver correlates well with enzyme activity in the mouse strains; hence, the expression of Adh-1 appears to be under transcriptional control. A restriction fragment polymorphism was found in mouse liver DNA which correlates with the content of ADH-AA in the high and low ADH activity strains.

Original languageEnglish
Pages (from-to)157-159
Number of pages3
JournalAlcohol and Alcoholism
VolumeSuppl 1
StatePublished - 1987

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Alcohol Dehydrogenase
Liver
Enzyme activity
Inbred DBA Mouse
Messenger RNA
Inbred Strains Mice
Enzymes
Polymorphism
Inbred C57BL Mouse
Isoenzymes
Complementary DNA
Genes
RNA
DNA

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Patterson, L. S., Zhang, K., Edenberg, H., & Bosron, W. F. (1987). Genetic control of liver alcohol dehydrogenase expression in inbred mice. Alcohol and Alcoholism, Suppl 1, 157-159.

Genetic control of liver alcohol dehydrogenase expression in inbred mice. / Patterson, L. S.; Zhang, K.; Edenberg, Howard; Bosron, W. F.

In: Alcohol and Alcoholism, Vol. Suppl 1, 1987, p. 157-159.

Research output: Contribution to journalArticle

Patterson, LS, Zhang, K, Edenberg, H & Bosron, WF 1987, 'Genetic control of liver alcohol dehydrogenase expression in inbred mice.', Alcohol and Alcoholism, vol. Suppl 1, pp. 157-159.
Patterson, L. S. ; Zhang, K. ; Edenberg, Howard ; Bosron, W. F. / Genetic control of liver alcohol dehydrogenase expression in inbred mice. In: Alcohol and Alcoholism. 1987 ; Vol. Suppl 1. pp. 157-159.
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