Genetic control of liver alcohol dehydrogenase expression in inbred mice.

L. S. Patterson, K. Zhang, H. J. Edenberg, W. F. Bosron

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The expression of the mouse Adh-1 gene which encodes the ADH-AA isoenzyme of liver alcohol dehydrogenase is under genetic control. The content of alcohol dehydrogenase in the C57BL inbred strain of mice is about twice that in DBA mice. In order to examine the mechanism for control of liver alcohol dehydrogenase expression in mice, we have isolated liver RNA from high and low enzyme activity strains and quantified the content of ADH mRNA with the ADH-A cDNA that was recently cloned in our laboratory. The content of ADH-A mRNA in liver correlates well with enzyme activity in the mouse strains; hence, the expression of Adh-1 appears to be under transcriptional control. A restriction fragment polymorphism was found in mouse liver DNA which correlates with the content of ADH-AA in the high and low ADH activity strains.

Original languageEnglish (US)
Pages (from-to)157-159
Number of pages3
JournalAlcohol and alcoholism (Oxford, Oxfordshire). Supplement.
Volume1
StatePublished - 1987

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

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