Genetic correlates of the development of theta event related oscillations in adolescents and young adults

David B. Chorlian, Madhavi Rangaswamy, Niklas Manz, Jacquelyn L. Meyers, Sun J. Kang, Chella Kamarajan, Ashwini K. Pandey, Jen Chyong Wang, Leah Wetherill, Howard Edenberg, Bernice Porjesz

Research output: Contribution to journalArticle

3 Scopus citations


The developmental trajectories of theta band (4–7 Hz) event-related oscillations (EROs), a key neurophysiological constituent of the P3 response, were assessed in 2170 adolescents and young adults ages 12 to 25. The theta EROs occurring in the P3 response, important indicators of neurocognitive function, were elicited during the evaluation of task-relevant target stimuli in visual and auditory oddball tasks. Associations between the theta EROs and genotypic variants of 4 KCNJ6 single nucleotide polymorphisms (SNPs) were found to vary with age, sex, scalp location, and task modality. Three of the four KCNJ6 SNPs studied here were found to be significantly associated with the same theta EROs in adults in a previous family genome wide association study. Since measures of the P3 response have been found to be a useful endophenotypes for the study of a number of clinical and behavioral disorders, studies of genetic effects on its development in adolescents and young adults may illuminate neurophysiological factors contributing to the onset of these conditions.

Original languageEnglish (US)
Pages (from-to)24-39
Number of pages16
JournalInternational Journal of Psychophysiology
StatePublished - May 1 2017



  • Adolescent
  • Development
  • ERO
  • KCNJ6
  • P3
  • Theta

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology
  • Physiology (medical)

Cite this

Chorlian, D. B., Rangaswamy, M., Manz, N., Meyers, J. L., Kang, S. J., Kamarajan, C., Pandey, A. K., Wang, J. C., Wetherill, L., Edenberg, H., & Porjesz, B. (2017). Genetic correlates of the development of theta event related oscillations in adolescents and young adults. International Journal of Psychophysiology, 115, 24-39.