Genetic correlations with ethanol withdrawal severity

John C. Crabbe, Emmett R. Young, Ann Kosobud

Research output: Contribution to journalArticle

79 Scopus citations

Abstract

A major goal of pharmacogenetic research on alcoholism remains the identification of some "marker" that could predict the liability of a particular individual for a genetic susceptibility to develop alcoholism. The present paper presents evidence that the severity of withdrawal from physical dependence on ethanol varies widely among inbred strains of mice, and that withdrawal severity is negatively genetically correlated with initial sensitivity and magnitude of tolerance to ethanol hypothermia. These correlations are supported by differences in hypothermic response between replicate lines of mice genetically selected for susceptibility and resistance to ethanol withdrawal seizures. The genetic relationships reported suggest that the effects of ethanol on thermoregulation in mice may offer a predictive marker for susceptibility to ethanol physical dependence.

Original languageEnglish (US)
Pages (from-to)541-547
Number of pages7
JournalPharmacology, Biochemistry and Behavior
Volume18
Issue numberSUPPL. 1
DOIs
StatePublished - 1983
Externally publishedYes

Keywords

  • Alcoholism
  • Animal models
  • Ethanol
  • Ethanol withdrawal syndrome
  • Genetic correlations
  • Genetics
  • Handling-induced convulsions
  • Hypothermia
  • Inbred mice
  • Pharmacogenetics
  • Tolerance
  • WSP/WSR selectively-bred mouse lines

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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