Genetic correlations with ethanol withdrawal severity

John C. Crabbe, Emmett R. Young, Ann Kosobud

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

A major goal of pharmacogenetic research on alcoholism remains the identification of some "marker" that could predict the liability of a particular individual for a genetic susceptibility to develop alcoholism. The present paper presents evidence that the severity of withdrawal from physical dependence on ethanol varies widely among inbred strains of mice, and that withdrawal severity is negatively genetically correlated with initial sensitivity and magnitude of tolerance to ethanol hypothermia. These correlations are supported by differences in hypothermic response between replicate lines of mice genetically selected for susceptibility and resistance to ethanol withdrawal seizures. The genetic relationships reported suggest that the effects of ethanol on thermoregulation in mice may offer a predictive marker for susceptibility to ethanol physical dependence.

Original languageEnglish (US)
Pages (from-to)541-547
Number of pages7
JournalPharmacology Biochemistry and Behavior
Volume18
Issue numberSUPPL. 1
DOIs
StatePublished - 1983
Externally publishedYes

Fingerprint

Ethanol
Alcoholism
Hypothermia
Inbred Strains Mice
Body Temperature Regulation
Pharmacogenetics
Genetic Predisposition to Disease
Seizures
Research

Keywords

  • Alcoholism
  • Animal models
  • Ethanol
  • Ethanol withdrawal syndrome
  • Genetic correlations
  • Genetics
  • Handling-induced convulsions
  • Hypothermia
  • Inbred mice
  • Pharmacogenetics
  • Tolerance
  • WSP/WSR selectively-bred mouse lines

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Genetic correlations with ethanol withdrawal severity. / Crabbe, John C.; Young, Emmett R.; Kosobud, Ann.

In: Pharmacology Biochemistry and Behavior, Vol. 18, No. SUPPL. 1, 1983, p. 541-547.

Research output: Contribution to journalArticle

Crabbe, John C. ; Young, Emmett R. ; Kosobud, Ann. / Genetic correlations with ethanol withdrawal severity. In: Pharmacology Biochemistry and Behavior. 1983 ; Vol. 18, No. SUPPL. 1. pp. 541-547.
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