Genetic factors in affective illness

Wade H. Berrttini, Lynn R. Goldin, John I. Nurnberger, Elliot S. Gershon

Research output: Contribution to journalArticle

6 Scopus citations


Research strategies for determining genetic vulnerability markers in affective illness are delineated. Using these strategies, recent developments in the biology of manic-depressive illness are discussed, including results from association and linkage studies, pharmacologic challenge protocols, and cerebrospinal fluid (CSF) data. Several lines of evidence suggest that one genetically determined vulnerability to affective disorder may be a cholinergic supersensitivity, possibly mediated through increased numbers of cholinergic receptors.

Original languageEnglish (US)
Pages (from-to)329-350
Number of pages22
JournalJournal of Psychiatric Research
Issue number4
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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