Genetic influences on bipolar EEG power spectra

Yongqiang Tang, David B. Chorlian, Madhavi Rangaswamy, Bernice Porjesz, Lance Bauer, Samuel Kuperman, Sean O'Connor, John Rohrbaugh, Marc Schuckit, Arthur Stimus, Henri Begleiter

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The EEG bipolar power spectra provide more localization than spectral measures obtained from monopolar referencing strategies, and have been shown to be useful endophenotypes of psychiatric disorders such as alcoholism. We estimated the additive genetic heritability of resting bipolar EEG power spectra in a large sample of non-twin sibling pairs. The corresponding heritabilities ranged between 0.220 and 0.647 and were highly significant at all 38 electrode pairs for theta (3-7 Hz), low-alpha (7-9 Hz), high-alpha (9-12 Hz), low-beta (12-16 Hz), middle-beta (16-20 Hz) and high-beta (20-28 Hz) frequency bands. The heritabilities were the highest in the high-alpha and low-beta bands at most electrode pairs. The heritabilities were most variable across the head in the three beta bands. Other heritability patterns were also identified within each frequency band. Our results suggest that substantial proportions of the variability in the bipolar EEG measures are explained by genetic factors.

Original languageEnglish (US)
Pages (from-to)2-9
Number of pages8
JournalInternational Journal of Psychophysiology
Volume65
Issue number1
DOIs
StatePublished - Jul 1 2007

Keywords

  • Bipolar EEG power spectra
  • Endophenotype
  • Heritability

ASJC Scopus subject areas

  • Behavioral Neuroscience

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    Tang, Y., Chorlian, D. B., Rangaswamy, M., Porjesz, B., Bauer, L., Kuperman, S., O'Connor, S., Rohrbaugh, J., Schuckit, M., Stimus, A., & Begleiter, H. (2007). Genetic influences on bipolar EEG power spectra. International Journal of Psychophysiology, 65(1), 2-9. https://doi.org/10.1016/j.ijpsycho.2007.02.004