Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls

E. Pettersson, P. Lichtenstein, H. Larsson, J. Song, A. Agrawal, A. D. Børglum, C. M. Bulik, M. J. Daly, L. K. Davis, D. Demontis, Howard Edenberg, J. Grove, J. Gelernter, B. M. Neale, A. F. Pardiñas, E. Stahl, J. T.R. Walters, R. Walters, P. F. Sullivan, D. Posthuma & 1 others T. J.C. Polderman

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

BackgroundMost studies underline the contribution of heritable factors for psychiatric disorders. However, heritability estimates depend on the population under study, diagnostic instruments, and study designs that each has its inherent assumptions, strengths, and biases. We aim to test the homogeneity in heritability estimates between two powerful, and state of the art study designs for eight psychiatric disorders.MethodsWe assessed heritability based on data of Swedish siblings (N = 4 408 646 full and maternal half-siblings), and based on summary data of eight samples with measured genotypes (N = 125 533 cases and 208 215 controls). All data were based on standard diagnostic criteria. Eight psychiatric disorders were studied: (1) alcohol dependence (AD), (2) anorexia nervosa, (3) attention deficit/hyperactivity disorder (ADHD), (4) autism spectrum disorder, (5) bipolar disorder, (6) major depressive disorder, (7) obsessive-compulsive disorder (OCD), and (8) schizophrenia.ResultsHeritability estimates from sibling data varied from 0.30 for Major Depression to 0.80 for ADHD. The estimates based on the measured genotypes were lower, ranging from 0.10 for AD to 0.28 for OCD, but were significant, and correlated positively (0.19) with national sibling-based estimates. When removing OCD from the data the correlation increased to 0.50.ConclusionsGiven the unique character of each study design, the convergent findings for these eight psychiatric conditions suggest that heritability estimates are robust across different methods. The findings also highlight large differences in genetic and environmental influences between psychiatric disorders, providing future directions for etiological psychiatric research.

Original languageEnglish (US)
JournalPsychological Medicine
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Psychiatry
Obsessive-Compulsive Disorder
Attention Deficit Disorder with Hyperactivity
Alcoholism
Genotype
Anorexia Nervosa
Major Depressive Disorder
Bipolar Disorder
Schizophrenia
Mothers
Depression
Research
Population

Keywords

  • ADHD
  • alcohol dependence
  • anorexia nervosa
  • autism spectrum disorders
  • bipolar disorder
  • genes
  • heritability
  • major depressive disorder
  • obsessive compulsive disorder
  • schizophrenia

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health

Cite this

Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls. / Pettersson, E.; Lichtenstein, P.; Larsson, H.; Song, J.; Agrawal, A.; Børglum, A. D.; Bulik, C. M.; Daly, M. J.; Davis, L. K.; Demontis, D.; Edenberg, Howard; Grove, J.; Gelernter, J.; Neale, B. M.; Pardiñas, A. F.; Stahl, E.; Walters, J. T.R.; Walters, R.; Sullivan, P. F.; Posthuma, D.; Polderman, T. J.C.

In: Psychological Medicine, 01.01.2018.

Research output: Contribution to journalArticle

Pettersson, E, Lichtenstein, P, Larsson, H, Song, J, Agrawal, A, Børglum, AD, Bulik, CM, Daly, MJ, Davis, LK, Demontis, D, Edenberg, H, Grove, J, Gelernter, J, Neale, BM, Pardiñas, AF, Stahl, E, Walters, JTR, Walters, R, Sullivan, PF, Posthuma, D & Polderman, TJC 2018, 'Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls', Psychological Medicine. https://doi.org/10.1017/S0033291718002039
Pettersson, E. ; Lichtenstein, P. ; Larsson, H. ; Song, J. ; Agrawal, A. ; Børglum, A. D. ; Bulik, C. M. ; Daly, M. J. ; Davis, L. K. ; Demontis, D. ; Edenberg, Howard ; Grove, J. ; Gelernter, J. ; Neale, B. M. ; Pardiñas, A. F. ; Stahl, E. ; Walters, J. T.R. ; Walters, R. ; Sullivan, P. F. ; Posthuma, D. ; Polderman, T. J.C. / Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls. In: Psychological Medicine. 2018.
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title = "Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls",
abstract = "BackgroundMost studies underline the contribution of heritable factors for psychiatric disorders. However, heritability estimates depend on the population under study, diagnostic instruments, and study designs that each has its inherent assumptions, strengths, and biases. We aim to test the homogeneity in heritability estimates between two powerful, and state of the art study designs for eight psychiatric disorders.MethodsWe assessed heritability based on data of Swedish siblings (N = 4 408 646 full and maternal half-siblings), and based on summary data of eight samples with measured genotypes (N = 125 533 cases and 208 215 controls). All data were based on standard diagnostic criteria. Eight psychiatric disorders were studied: (1) alcohol dependence (AD), (2) anorexia nervosa, (3) attention deficit/hyperactivity disorder (ADHD), (4) autism spectrum disorder, (5) bipolar disorder, (6) major depressive disorder, (7) obsessive-compulsive disorder (OCD), and (8) schizophrenia.ResultsHeritability estimates from sibling data varied from 0.30 for Major Depression to 0.80 for ADHD. The estimates based on the measured genotypes were lower, ranging from 0.10 for AD to 0.28 for OCD, but were significant, and correlated positively (0.19) with national sibling-based estimates. When removing OCD from the data the correlation increased to 0.50.ConclusionsGiven the unique character of each study design, the convergent findings for these eight psychiatric conditions suggest that heritability estimates are robust across different methods. The findings also highlight large differences in genetic and environmental influences between psychiatric disorders, providing future directions for etiological psychiatric research.",
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author = "E. Pettersson and P. Lichtenstein and H. Larsson and J. Song and A. Agrawal and B{\o}rglum, {A. D.} and Bulik, {C. M.} and Daly, {M. J.} and Davis, {L. K.} and D. Demontis and Howard Edenberg and J. Grove and J. Gelernter and Neale, {B. M.} and Pardi{\~n}as, {A. F.} and E. Stahl and Walters, {J. T.R.} and R. Walters and Sullivan, {P. F.} and D. Posthuma and Polderman, {T. J.C.}",
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T1 - Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls

AU - Pettersson, E.

AU - Lichtenstein, P.

AU - Larsson, H.

AU - Song, J.

AU - Agrawal, A.

AU - Børglum, A. D.

AU - Bulik, C. M.

AU - Daly, M. J.

AU - Davis, L. K.

AU - Demontis, D.

AU - Edenberg, Howard

AU - Grove, J.

AU - Gelernter, J.

AU - Neale, B. M.

AU - Pardiñas, A. F.

AU - Stahl, E.

AU - Walters, J. T.R.

AU - Walters, R.

AU - Sullivan, P. F.

AU - Posthuma, D.

AU - Polderman, T. J.C.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - BackgroundMost studies underline the contribution of heritable factors for psychiatric disorders. However, heritability estimates depend on the population under study, diagnostic instruments, and study designs that each has its inherent assumptions, strengths, and biases. We aim to test the homogeneity in heritability estimates between two powerful, and state of the art study designs for eight psychiatric disorders.MethodsWe assessed heritability based on data of Swedish siblings (N = 4 408 646 full and maternal half-siblings), and based on summary data of eight samples with measured genotypes (N = 125 533 cases and 208 215 controls). All data were based on standard diagnostic criteria. Eight psychiatric disorders were studied: (1) alcohol dependence (AD), (2) anorexia nervosa, (3) attention deficit/hyperactivity disorder (ADHD), (4) autism spectrum disorder, (5) bipolar disorder, (6) major depressive disorder, (7) obsessive-compulsive disorder (OCD), and (8) schizophrenia.ResultsHeritability estimates from sibling data varied from 0.30 for Major Depression to 0.80 for ADHD. The estimates based on the measured genotypes were lower, ranging from 0.10 for AD to 0.28 for OCD, but were significant, and correlated positively (0.19) with national sibling-based estimates. When removing OCD from the data the correlation increased to 0.50.ConclusionsGiven the unique character of each study design, the convergent findings for these eight psychiatric conditions suggest that heritability estimates are robust across different methods. The findings also highlight large differences in genetic and environmental influences between psychiatric disorders, providing future directions for etiological psychiatric research.

AB - BackgroundMost studies underline the contribution of heritable factors for psychiatric disorders. However, heritability estimates depend on the population under study, diagnostic instruments, and study designs that each has its inherent assumptions, strengths, and biases. We aim to test the homogeneity in heritability estimates between two powerful, and state of the art study designs for eight psychiatric disorders.MethodsWe assessed heritability based on data of Swedish siblings (N = 4 408 646 full and maternal half-siblings), and based on summary data of eight samples with measured genotypes (N = 125 533 cases and 208 215 controls). All data were based on standard diagnostic criteria. Eight psychiatric disorders were studied: (1) alcohol dependence (AD), (2) anorexia nervosa, (3) attention deficit/hyperactivity disorder (ADHD), (4) autism spectrum disorder, (5) bipolar disorder, (6) major depressive disorder, (7) obsessive-compulsive disorder (OCD), and (8) schizophrenia.ResultsHeritability estimates from sibling data varied from 0.30 for Major Depression to 0.80 for ADHD. The estimates based on the measured genotypes were lower, ranging from 0.10 for AD to 0.28 for OCD, but were significant, and correlated positively (0.19) with national sibling-based estimates. When removing OCD from the data the correlation increased to 0.50.ConclusionsGiven the unique character of each study design, the convergent findings for these eight psychiatric conditions suggest that heritability estimates are robust across different methods. The findings also highlight large differences in genetic and environmental influences between psychiatric disorders, providing future directions for etiological psychiatric research.

KW - ADHD

KW - alcohol dependence

KW - anorexia nervosa

KW - autism spectrum disorders

KW - bipolar disorder

KW - genes

KW - heritability

KW - major depressive disorder

KW - obsessive compulsive disorder

KW - schizophrenia

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U2 - 10.1017/S0033291718002039

DO - 10.1017/S0033291718002039

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JO - Psychological Medicine

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