Genetic influences on schizophrenia and subcortical brain volumes

Large-scale proof of concept

Barbara Franke, Jason L. Stein, Stephan Ripke, Verneri Anttila, Derrek P. Hibar, Kimm J E Van Hulzen, Alejandro Arias-Vasquez, Jordan W. Smoller, Thomas E. Nichols, Michael C. Neale, Andrew M. McIntosh, Phil Lee, Francis J. McMahon, Andreas Meyer-Lindenberg, Manuel Mattheisen, Ole A. Andreassen, Oliver Gruber, Perminder S. Sachdev, Roberto Roiz-Santiañez, Andrew J. Saykin & 14 others Stefan Ehrlich, Karen A. Mather, Jessica A. Turner, Emanuel Schwarz, Anbupalam Thalamuthu, Yin Yao, Yvonne Y W Ho, Nicholas G. Martin, Margaret J. Wright, Michael C. O'Donovan, Paul M. Thompson, Benjamin M. Neale, Sarah E. Medland, Tatiana Foroud

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders.

Original languageEnglish (US)
Pages (from-to)420-431
Number of pages12
JournalNature Neuroscience
Volume19
Issue number3
DOIs
StatePublished - Feb 23 2016

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Schizophrenia
Brain
Psychiatry
Phenotype
Genetic Markers
Neuroimaging
Genome

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Franke, B., Stein, J. L., Ripke, S., Anttila, V., Hibar, D. P., Van Hulzen, K. J. E., ... Foroud, T. (2016). Genetic influences on schizophrenia and subcortical brain volumes: Large-scale proof of concept. Nature Neuroscience, 19(3), 420-431. https://doi.org/10.1038/nn.4228

Genetic influences on schizophrenia and subcortical brain volumes : Large-scale proof of concept. / Franke, Barbara; Stein, Jason L.; Ripke, Stephan; Anttila, Verneri; Hibar, Derrek P.; Van Hulzen, Kimm J E; Arias-Vasquez, Alejandro; Smoller, Jordan W.; Nichols, Thomas E.; Neale, Michael C.; McIntosh, Andrew M.; Lee, Phil; McMahon, Francis J.; Meyer-Lindenberg, Andreas; Mattheisen, Manuel; Andreassen, Ole A.; Gruber, Oliver; Sachdev, Perminder S.; Roiz-Santiañez, Roberto; Saykin, Andrew J.; Ehrlich, Stefan; Mather, Karen A.; Turner, Jessica A.; Schwarz, Emanuel; Thalamuthu, Anbupalam; Yao, Yin; Ho, Yvonne Y W; Martin, Nicholas G.; Wright, Margaret J.; O'Donovan, Michael C.; Thompson, Paul M.; Neale, Benjamin M.; Medland, Sarah E.; Foroud, Tatiana.

In: Nature Neuroscience, Vol. 19, No. 3, 23.02.2016, p. 420-431.

Research output: Contribution to journalArticle

Franke, B, Stein, JL, Ripke, S, Anttila, V, Hibar, DP, Van Hulzen, KJE, Arias-Vasquez, A, Smoller, JW, Nichols, TE, Neale, MC, McIntosh, AM, Lee, P, McMahon, FJ, Meyer-Lindenberg, A, Mattheisen, M, Andreassen, OA, Gruber, O, Sachdev, PS, Roiz-Santiañez, R, Saykin, AJ, Ehrlich, S, Mather, KA, Turner, JA, Schwarz, E, Thalamuthu, A, Yao, Y, Ho, YYW, Martin, NG, Wright, MJ, O'Donovan, MC, Thompson, PM, Neale, BM, Medland, SE & Foroud, T 2016, 'Genetic influences on schizophrenia and subcortical brain volumes: Large-scale proof of concept', Nature Neuroscience, vol. 19, no. 3, pp. 420-431. https://doi.org/10.1038/nn.4228
Franke B, Stein JL, Ripke S, Anttila V, Hibar DP, Van Hulzen KJE et al. Genetic influences on schizophrenia and subcortical brain volumes: Large-scale proof of concept. Nature Neuroscience. 2016 Feb 23;19(3):420-431. https://doi.org/10.1038/nn.4228
Franke, Barbara ; Stein, Jason L. ; Ripke, Stephan ; Anttila, Verneri ; Hibar, Derrek P. ; Van Hulzen, Kimm J E ; Arias-Vasquez, Alejandro ; Smoller, Jordan W. ; Nichols, Thomas E. ; Neale, Michael C. ; McIntosh, Andrew M. ; Lee, Phil ; McMahon, Francis J. ; Meyer-Lindenberg, Andreas ; Mattheisen, Manuel ; Andreassen, Ole A. ; Gruber, Oliver ; Sachdev, Perminder S. ; Roiz-Santiañez, Roberto ; Saykin, Andrew J. ; Ehrlich, Stefan ; Mather, Karen A. ; Turner, Jessica A. ; Schwarz, Emanuel ; Thalamuthu, Anbupalam ; Yao, Yin ; Ho, Yvonne Y W ; Martin, Nicholas G. ; Wright, Margaret J. ; O'Donovan, Michael C. ; Thompson, Paul M. ; Neale, Benjamin M. ; Medland, Sarah E. ; Foroud, Tatiana. / Genetic influences on schizophrenia and subcortical brain volumes : Large-scale proof of concept. In: Nature Neuroscience. 2016 ; Vol. 19, No. 3. pp. 420-431.
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