Genetic polymorphisms in ZFHX3 are associated with atrial fibrillation in a Chinese Han population

Yaowu Liu, Bixian Ni, Yuan Lin, Xin Guang Chen, Zhen Fang, Liyan Zhao, Zhibin Hu, Fengxiang Zhang

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: The gene zinc finger homeobox 3 (ZFHX3) encodes a transcription factor with cardiac expression and its genetic variants are associated with atrial fibrillation (AF). We aimed to explore the associations between single nucleotide polymorphisms (SNPs) of ZFHX3 and the risk of AF in a Chinese Han population. Methods: We genotyped eight SNPs, including seven potentially functional SNPs and one previously reported SNP by using the middle-throughput iPLEX Sequenom MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in logistic regression models. Results: We enrolled a total of 1,593 Chinese Han origin individuals in the study, including 597 AF patients and 996 non-AF controls. Logistic regression analyses revealed that potentially functional SNPs rs6499600 and rs16971436 were associated with a decreased risk of AF (adjusted OR = 0.73, 95% CI: 0.63-0.86, P = 1.07×10-4; adjusted OR = 0.74, 95% CI: 0.56-0.98, P = 0.039, respectively). In addition, rs2106261 showed a robust association with an increased risk of AF (adjusted OR = 1.71, 95% CI: 1.46-2.00, P = 1.85×10-11). After multiple comparisons, rs16971436 conferred a borderline significant association with the risk of AF. Stratification analysis indicated that the risks of AF were statistically different among subgroups of age for rs2106261, and the effect for rs16971436 was more evident in subgroups of patients with coronary artery disease. Conclusion: In summary, our study investigated the role of genetic variants of ZFHX3 in AF and two SNPs (rs2106261, rs6499600) showed significant associations while rs16971436 conferred a borderline significant association with AF risk in Chinese Han populations. However, further large and functional studies are warranted to confirm our findings.

Original languageEnglish (US)
Article numbere101318
JournalPLoS One
Volume9
Issue number7
DOIs
StatePublished - Jul 1 2014
Externally publishedYes

Fingerprint

Homeobox Genes
zinc finger motif
Zinc Fingers
Genetic Polymorphisms
Polymorphism
Atrial Fibrillation
Zinc
Nucleotides
genetic polymorphism
single nucleotide polymorphism
Single Nucleotide Polymorphism
Population
odds ratio
confidence interval
Odds Ratio
Confidence Intervals
Logistics
Logistic Models
atrial fibrillation
Transcription Factors

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Genetic polymorphisms in ZFHX3 are associated with atrial fibrillation in a Chinese Han population. / Liu, Yaowu; Ni, Bixian; Lin, Yuan; Chen, Xin Guang; Fang, Zhen; Zhao, Liyan; Hu, Zhibin; Zhang, Fengxiang.

In: PLoS One, Vol. 9, No. 7, e101318, 01.07.2014.

Research output: Contribution to journalArticle

Liu, Yaowu ; Ni, Bixian ; Lin, Yuan ; Chen, Xin Guang ; Fang, Zhen ; Zhao, Liyan ; Hu, Zhibin ; Zhang, Fengxiang. / Genetic polymorphisms in ZFHX3 are associated with atrial fibrillation in a Chinese Han population. In: PLoS One. 2014 ; Vol. 9, No. 7.
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abstract = "Background: The gene zinc finger homeobox 3 (ZFHX3) encodes a transcription factor with cardiac expression and its genetic variants are associated with atrial fibrillation (AF). We aimed to explore the associations between single nucleotide polymorphisms (SNPs) of ZFHX3 and the risk of AF in a Chinese Han population. Methods: We genotyped eight SNPs, including seven potentially functional SNPs and one previously reported SNP by using the middle-throughput iPLEX Sequenom MassARRAY platform. Odds ratios (ORs) and 95{\%} confidence intervals (CIs) were calculated in logistic regression models. Results: We enrolled a total of 1,593 Chinese Han origin individuals in the study, including 597 AF patients and 996 non-AF controls. Logistic regression analyses revealed that potentially functional SNPs rs6499600 and rs16971436 were associated with a decreased risk of AF (adjusted OR = 0.73, 95{\%} CI: 0.63-0.86, P = 1.07×10-4; adjusted OR = 0.74, 95{\%} CI: 0.56-0.98, P = 0.039, respectively). In addition, rs2106261 showed a robust association with an increased risk of AF (adjusted OR = 1.71, 95{\%} CI: 1.46-2.00, P = 1.85×10-11). After multiple comparisons, rs16971436 conferred a borderline significant association with the risk of AF. Stratification analysis indicated that the risks of AF were statistically different among subgroups of age for rs2106261, and the effect for rs16971436 was more evident in subgroups of patients with coronary artery disease. Conclusion: In summary, our study investigated the role of genetic variants of ZFHX3 in AF and two SNPs (rs2106261, rs6499600) showed significant associations while rs16971436 conferred a borderline significant association with AF risk in Chinese Han populations. However, further large and functional studies are warranted to confirm our findings.",
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T1 - Genetic polymorphisms in ZFHX3 are associated with atrial fibrillation in a Chinese Han population

AU - Liu, Yaowu

AU - Ni, Bixian

AU - Lin, Yuan

AU - Chen, Xin Guang

AU - Fang, Zhen

AU - Zhao, Liyan

AU - Hu, Zhibin

AU - Zhang, Fengxiang

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AB - Background: The gene zinc finger homeobox 3 (ZFHX3) encodes a transcription factor with cardiac expression and its genetic variants are associated with atrial fibrillation (AF). We aimed to explore the associations between single nucleotide polymorphisms (SNPs) of ZFHX3 and the risk of AF in a Chinese Han population. Methods: We genotyped eight SNPs, including seven potentially functional SNPs and one previously reported SNP by using the middle-throughput iPLEX Sequenom MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in logistic regression models. Results: We enrolled a total of 1,593 Chinese Han origin individuals in the study, including 597 AF patients and 996 non-AF controls. Logistic regression analyses revealed that potentially functional SNPs rs6499600 and rs16971436 were associated with a decreased risk of AF (adjusted OR = 0.73, 95% CI: 0.63-0.86, P = 1.07×10-4; adjusted OR = 0.74, 95% CI: 0.56-0.98, P = 0.039, respectively). In addition, rs2106261 showed a robust association with an increased risk of AF (adjusted OR = 1.71, 95% CI: 1.46-2.00, P = 1.85×10-11). After multiple comparisons, rs16971436 conferred a borderline significant association with the risk of AF. Stratification analysis indicated that the risks of AF were statistically different among subgroups of age for rs2106261, and the effect for rs16971436 was more evident in subgroups of patients with coronary artery disease. Conclusion: In summary, our study investigated the role of genetic variants of ZFHX3 in AF and two SNPs (rs2106261, rs6499600) showed significant associations while rs16971436 conferred a borderline significant association with AF risk in Chinese Han populations. However, further large and functional studies are warranted to confirm our findings.

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