Genetic predisposition to external apical root resorption in orthodontic patients: Linkage of chromosome-18 marker

R. A. Al-Qawasmi, J. K. Hartsfield, E. T. Everett, L. Flury, L. Liu, T. M. Foroud, J. V. Macri, W. E. Roberts

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

External apical root resorption (EARR) is a common orthodontic treatment sequela. Previous studies implicate a substantial genetic component for EARR. Using a candidate gene approach, we investigated possible linkage of EARR associated with orthodontic treatment with the TNSALP, TNFα, and TNFRSF11A gene loci. The sample was comprised of 38 American Caucasian families with a total of 79 siblings who completed comprehensive orthodontic treatment. EARR was assessed by means of pre- and post-treatment radiographs. Buccal swab cells were collected for extraction and analysis of DNA. No evidence of linkage was found with EARR and the TNFa and TNSALP genes. Non-parametric sibling pair linkage analysis identified evidence of linkage (LOD = 2.5; p = 0.02) of EARR affecting the maxillary central incisor with the microsatellite marker D18S64 (tightly linked to TNFRSF11A). This indicates that the TNFRSF11A locus, or another tightly linked gene, is associated with EARR.

Original languageEnglish (US)
Pages (from-to)356-360
Number of pages5
JournalJournal of dental research
Volume82
Issue number5
DOIs
StatePublished - May 2003

Keywords

  • Chromosome 18
  • Linkage
  • Orthodontics
  • RANK
  • Root resorption

ASJC Scopus subject areas

  • Dentistry(all)

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