Genetic profiles in renal tumors: Review Article

Antonio Lopez-Beltran, Rodolfo Montironi, Lars Egevad, Maria T. Caballero-Vargas, Marina Scarpelli, Ziya Kirkali, Liang Cheng

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Renal cell carcinoma in adult comprises a heterogeneous group of tumors with variable clinical outcomes, which ranges from indolent to aggressively malignant. The application of molecular genetics techniques to the study of renal neoplasms has resulted in improved classification of these entities and better understanding of biological mechanisms responsible for tumor development and progression. In the present article we review the molecular genetic profiles of different renal cell tumors and discuss their relevance to the carcinogenesis mechanisms and to the clinical diagnosis of renal cell carcinoma. Understanding of the molecular genetics of renal tumors is beneficial in making accurate diagnoses, assessing prognoses, and selecting appropriate and targeted therapeutic options.

Original languageEnglish (US)
Pages (from-to)6-19
Number of pages14
JournalInternational Journal of Urology
Volume17
Issue number1
DOIs
StatePublished - Jan 1 2010

Keywords

  • Classification
  • Differential diagnosis
  • Kidney
  • Molecular genetics
  • Renal neoplasms
  • Tumor origin

ASJC Scopus subject areas

  • Urology

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    Lopez-Beltran, A., Montironi, R., Egevad, L., Caballero-Vargas, M. T., Scarpelli, M., Kirkali, Z., & Cheng, L. (2010). Genetic profiles in renal tumors: Review Article. International Journal of Urology, 17(1), 6-19. https://doi.org/10.1111/j.1442-2042.2009.02395.x