Genetic Risk Score Predicts Late-Life Cognitive Impairment

Mariegold E. Wollam, Andrea M. Weinstein, Judith A. Saxton, Lisa Morrow, Beth Snitz, Nicole R. Fowler, Barbara L. Suever Erickson, Kathryn A. Roecklein, Kirk I. Erickson

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Abstract

Introduction. A family history of Alzheimer's disease is a significant risk factor for its onset, but the genetic risk associated with possessing multiple risk alleles is still poorly understood. Methods. In a sample of 95 older adults (Mean age = 75.1, 64.2% female), we constructed a genetic risk score based on the accumulation of risk alleles in BDNF, COMT, and APOE. A neuropsychological evaluation and consensus determined cognitive status (44 nonimpaired, 51 impaired). Logistic regression was performed to determine whether the genetic risk score predicted cognitive impairment above and beyond that associated with each gene. Results. An increased genetic risk score was associated with a nearly 4-fold increased risk of cognitive impairment (OR = 3.824, P =.013) when including the individual gene polymorphisms as covariates in the model. Discussion. A risk score combining multiple genetic influences may be more useful in predicting late-life cognitive impairment than individual polymorphisms.

Original languageEnglish (US)
Article number267062
JournalJournal of Aging Research
Volume2015
DOIs
StatePublished - Jan 1 2015

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ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Wollam, M. E., Weinstein, A. M., Saxton, J. A., Morrow, L., Snitz, B., Fowler, N. R., Suever Erickson, B. L., Roecklein, K. A., & Erickson, K. I. (2015). Genetic Risk Score Predicts Late-Life Cognitive Impairment. Journal of Aging Research, 2015, [267062]. https://doi.org/10.1155/2015/267062