Genetic Testing in Pediatric Left Ventricular Noncompaction

Erin M. Miller, Robert B. Hinton, Richard Czosek, Angela Lorts, Ashley Parrott, Amy R. Shikany, Richard F. Ittenbach, Stephanie Ware

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background - Left ventricular noncompaction (LVNC) can occur in isolation or can co-occur with a cardiomyopathy phenotype or cardiovascular malformation. The yield of cardiomyopathy gene panel testing in infants, children, and adolescents with a diagnosis of LVNC is unknown. By characterizing a pediatric population with LVNC, we sought to determine the yield of cardiomyopathy gene panel testing, distinguish the yield of testing for LVNC with or without co-occurring cardiac findings, and define additional factors influencing genetic testing yield. Methods and Results - One hundred twenty-eight individuals diagnosed with LVNC at ≤21 years of age were identified, including 59% with idiopathic etiology, 32% with familial disease, and 9% with a syndromic or metabolic diagnosis. Overall, 75 individuals had either cardiomyopathy gene panel (n=65) or known variant testing (n=10). The yield of cardiomyopathy gene panel testing was 9%. The severity of LVNC by imaging criteria was not associated with positive genetic testing, co-occurring cardiac features, etiology, family history, or myocardial dysfunction. Individuals with isolated LVNC were significantly less likely to have a positive genetic testing result compared with those with LVNC and co-occurring cardiomyopathy (0% versus 12%, respectively; P<0.01). Conclusions - Genetic testing should be considered in individuals with cardiomyopathy co-occurring with LVNC. These data do not suggest an indication for cardiomyopathy gene panel testing in individuals with isolated LVNC in the absence of a family history of cardiomyopathy.

Original languageEnglish (US)
Article numbere001735
JournalCirculation: Cardiovascular Genetics
Volume10
Issue number6
DOIs
StatePublished - Dec 1 2017

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Genetic Testing
Cardiomyopathies
Pediatrics
Genes
Phenotype

Keywords

  • cardiomyopathies
  • genetic testing
  • infant
  • pediatrics
  • phenotype

ASJC Scopus subject areas

  • Genetics
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)

Cite this

Miller, E. M., Hinton, R. B., Czosek, R., Lorts, A., Parrott, A., Shikany, A. R., ... Ware, S. (2017). Genetic Testing in Pediatric Left Ventricular Noncompaction. Circulation: Cardiovascular Genetics, 10(6), [e001735]. https://doi.org/10.1161/CIRCGENETICS.117.001735

Genetic Testing in Pediatric Left Ventricular Noncompaction. / Miller, Erin M.; Hinton, Robert B.; Czosek, Richard; Lorts, Angela; Parrott, Ashley; Shikany, Amy R.; Ittenbach, Richard F.; Ware, Stephanie.

In: Circulation: Cardiovascular Genetics, Vol. 10, No. 6, e001735, 01.12.2017.

Research output: Contribution to journalArticle

Miller, EM, Hinton, RB, Czosek, R, Lorts, A, Parrott, A, Shikany, AR, Ittenbach, RF & Ware, S 2017, 'Genetic Testing in Pediatric Left Ventricular Noncompaction', Circulation: Cardiovascular Genetics, vol. 10, no. 6, e001735. https://doi.org/10.1161/CIRCGENETICS.117.001735
Miller EM, Hinton RB, Czosek R, Lorts A, Parrott A, Shikany AR et al. Genetic Testing in Pediatric Left Ventricular Noncompaction. Circulation: Cardiovascular Genetics. 2017 Dec 1;10(6). e001735. https://doi.org/10.1161/CIRCGENETICS.117.001735
Miller, Erin M. ; Hinton, Robert B. ; Czosek, Richard ; Lorts, Angela ; Parrott, Ashley ; Shikany, Amy R. ; Ittenbach, Richard F. ; Ware, Stephanie. / Genetic Testing in Pediatric Left Ventricular Noncompaction. In: Circulation: Cardiovascular Genetics. 2017 ; Vol. 10, No. 6.
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