Genetic variability in energy balance and pancreatic cancer risk in a population-based case-control study in Minnesota

Jianjun Zhang , Ishwori B. Dhakal, Xuemei Zhang, Anna E. Prizment, Kristin E. Anderson

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

OBJECTIVES: Accumulating evidence suggests that energy imbalance plays a role in pancreatic carcinogenesis. However, it remains unclear whether single-nucleotide polymorphisms (SNPs) in genes regulating energy homeostasis influence pancreatic cancer risk. We investigated this question in a case-control study conducted from 1994 to 1998. METHODS: Patients (n = 173) were ascertained from hospitals in the Twin Cities and Mayo Clinic, Minnesota. Control subjects (n = 476) were identified from the general population and frequency matched to patients by age and sex. Seven SNPs were evaluated in relation to pancreatic cancer using unconditional logistic regression. RESULTS: After adjustment for confounders, the leucine/proline or proline/proline genotype of the neuropeptide Y (NPY) gene rs16139 was associated with a lower risk than the leucine/leucine genotype (odds ratio, 0.40 [95% confidence interval, 0.15-0.91]). Conversely, an increased risk was observed for the glycine/arginine or arginine/arginine genotype of the adrenoceptor β2, surface (ADRB2) gene rs1042713 as compared with the glycine/glycine genotype (odds ratio, 1.52 [95% confidence interval, 1.01-2.31]). CONCLUSIONS: This study first reveals that SNPs in genes modulating energy intake (NPY) and energy expenditure (ADRB2) altered pancreatic cancer risk. If confirmed by other studies, our findings may shed new light on the etiology and prevention of pancreatic cancer.

Original languageEnglish
Pages (from-to)281-286
Number of pages6
JournalPancreas
Volume43
Issue number2
DOIs
StatePublished - Mar 2014

Fingerprint

Pancreatic Neoplasms
Case-Control Studies
Genotype
Proline
Leucine
Glycine
Single Nucleotide Polymorphism
Arginine
Neuropeptide Y
Population
Genes
Odds Ratio
Confidence Intervals
Energy Intake
Adrenergic Receptors
Energy Metabolism
Carcinogenesis
Homeostasis
Logistic Models

Keywords

  • case-control study
  • energy balance
  • obesity
  • pancreatic cancer
  • polymorphisms

ASJC Scopus subject areas

  • Hepatology
  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Genetic variability in energy balance and pancreatic cancer risk in a population-based case-control study in Minnesota. / Zhang , Jianjun; Dhakal, Ishwori B.; Zhang, Xuemei; Prizment, Anna E.; Anderson, Kristin E.

In: Pancreas, Vol. 43, No. 2, 03.2014, p. 281-286.

Research output: Contribution to journalArticle

Zhang , Jianjun ; Dhakal, Ishwori B. ; Zhang, Xuemei ; Prizment, Anna E. ; Anderson, Kristin E. / Genetic variability in energy balance and pancreatic cancer risk in a population-based case-control study in Minnesota. In: Pancreas. 2014 ; Vol. 43, No. 2. pp. 281-286.
@article{5f89ddbf3511473d81e13216f0dc4c1d,
title = "Genetic variability in energy balance and pancreatic cancer risk in a population-based case-control study in Minnesota",
abstract = "OBJECTIVES: Accumulating evidence suggests that energy imbalance plays a role in pancreatic carcinogenesis. However, it remains unclear whether single-nucleotide polymorphisms (SNPs) in genes regulating energy homeostasis influence pancreatic cancer risk. We investigated this question in a case-control study conducted from 1994 to 1998. METHODS: Patients (n = 173) were ascertained from hospitals in the Twin Cities and Mayo Clinic, Minnesota. Control subjects (n = 476) were identified from the general population and frequency matched to patients by age and sex. Seven SNPs were evaluated in relation to pancreatic cancer using unconditional logistic regression. RESULTS: After adjustment for confounders, the leucine/proline or proline/proline genotype of the neuropeptide Y (NPY) gene rs16139 was associated with a lower risk than the leucine/leucine genotype (odds ratio, 0.40 [95{\%} confidence interval, 0.15-0.91]). Conversely, an increased risk was observed for the glycine/arginine or arginine/arginine genotype of the adrenoceptor β2, surface (ADRB2) gene rs1042713 as compared with the glycine/glycine genotype (odds ratio, 1.52 [95{\%} confidence interval, 1.01-2.31]). CONCLUSIONS: This study first reveals that SNPs in genes modulating energy intake (NPY) and energy expenditure (ADRB2) altered pancreatic cancer risk. If confirmed by other studies, our findings may shed new light on the etiology and prevention of pancreatic cancer.",
keywords = "case-control study, energy balance, obesity, pancreatic cancer, polymorphisms",
author = "Jianjun Zhang  and Dhakal, {Ishwori B.} and Xuemei Zhang and Prizment, {Anna E.} and Anderson, {Kristin E.}",
year = "2014",
month = "3",
doi = "10.1097/MPA.0b013e3182a7c829",
language = "English",
volume = "43",
pages = "281--286",
journal = "Pancreas",
issn = "0885-3177",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Genetic variability in energy balance and pancreatic cancer risk in a population-based case-control study in Minnesota

AU - Zhang , Jianjun

AU - Dhakal, Ishwori B.

AU - Zhang, Xuemei

AU - Prizment, Anna E.

AU - Anderson, Kristin E.

PY - 2014/3

Y1 - 2014/3

N2 - OBJECTIVES: Accumulating evidence suggests that energy imbalance plays a role in pancreatic carcinogenesis. However, it remains unclear whether single-nucleotide polymorphisms (SNPs) in genes regulating energy homeostasis influence pancreatic cancer risk. We investigated this question in a case-control study conducted from 1994 to 1998. METHODS: Patients (n = 173) were ascertained from hospitals in the Twin Cities and Mayo Clinic, Minnesota. Control subjects (n = 476) were identified from the general population and frequency matched to patients by age and sex. Seven SNPs were evaluated in relation to pancreatic cancer using unconditional logistic regression. RESULTS: After adjustment for confounders, the leucine/proline or proline/proline genotype of the neuropeptide Y (NPY) gene rs16139 was associated with a lower risk than the leucine/leucine genotype (odds ratio, 0.40 [95% confidence interval, 0.15-0.91]). Conversely, an increased risk was observed for the glycine/arginine or arginine/arginine genotype of the adrenoceptor β2, surface (ADRB2) gene rs1042713 as compared with the glycine/glycine genotype (odds ratio, 1.52 [95% confidence interval, 1.01-2.31]). CONCLUSIONS: This study first reveals that SNPs in genes modulating energy intake (NPY) and energy expenditure (ADRB2) altered pancreatic cancer risk. If confirmed by other studies, our findings may shed new light on the etiology and prevention of pancreatic cancer.

AB - OBJECTIVES: Accumulating evidence suggests that energy imbalance plays a role in pancreatic carcinogenesis. However, it remains unclear whether single-nucleotide polymorphisms (SNPs) in genes regulating energy homeostasis influence pancreatic cancer risk. We investigated this question in a case-control study conducted from 1994 to 1998. METHODS: Patients (n = 173) were ascertained from hospitals in the Twin Cities and Mayo Clinic, Minnesota. Control subjects (n = 476) were identified from the general population and frequency matched to patients by age and sex. Seven SNPs were evaluated in relation to pancreatic cancer using unconditional logistic regression. RESULTS: After adjustment for confounders, the leucine/proline or proline/proline genotype of the neuropeptide Y (NPY) gene rs16139 was associated with a lower risk than the leucine/leucine genotype (odds ratio, 0.40 [95% confidence interval, 0.15-0.91]). Conversely, an increased risk was observed for the glycine/arginine or arginine/arginine genotype of the adrenoceptor β2, surface (ADRB2) gene rs1042713 as compared with the glycine/glycine genotype (odds ratio, 1.52 [95% confidence interval, 1.01-2.31]). CONCLUSIONS: This study first reveals that SNPs in genes modulating energy intake (NPY) and energy expenditure (ADRB2) altered pancreatic cancer risk. If confirmed by other studies, our findings may shed new light on the etiology and prevention of pancreatic cancer.

KW - case-control study

KW - energy balance

KW - obesity

KW - pancreatic cancer

KW - polymorphisms

UR - http://www.scopus.com/inward/record.url?scp=84894417711&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84894417711&partnerID=8YFLogxK

U2 - 10.1097/MPA.0b013e3182a7c829

DO - 10.1097/MPA.0b013e3182a7c829

M3 - Article

VL - 43

SP - 281

EP - 286

JO - Pancreas

JF - Pancreas

SN - 0885-3177

IS - 2

ER -