Genetic variant in fat mass and obesity-associated gene associated with type 2 diabetes risk in han chinese

Yun Qian, Sijun Liu, Feng Lu, Huizhang Li, Meihua Dong, Yudi Lin, Jiangbo Du, Yuan Lin, Jianhang Gong, Guangfu Jin, Juncheng Dai, Zhibin Hu, Hongbing Shen

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Genome-wide association study (GWAS) has identified that rs8050136 C/A polymorphism in fat mass and obesity-associated gene (FTO) was associated with the risk of type 2 diabetes (T2D) in Europeans. But this association was abolished after adjustment for body mass index (BMI), suggesting that the effect of rs8050136 on T2D risk might be mediated by BMI in Europeans. However, the findings in subsequent studies were inconsistent among Asian populations. To determine whether rs8050136 polymorphism in FTO is independently associated with the risk of T2D in Chinese, we conducted a case-control study with 2,925 T2D patients and 3,281 controls in Han Chinese.Results: Logistic regression revealed that the A allele of rs8050136 was significantly associated with an increased risk of T2D, independent of BMI (odds ratio (OR) = 1.17, 95% confidence interval (95% CI) = 1.03-1.32, p = 0.016). Meta-analysis containing 10 reported studies and our data with a total of 15,819 cases and 18,314 controls further confirmed the association between rs8050136 polymorphism and T2D risk in East Asians (OR = 1.13, 95% CI = 1.07-1.19).Conclusions: Our findings indicate that the genetic variant in FTO may contribute to T2D risk in Han Chinese and rs8050136 polymorphism may be a genetic marker for T2D susceptibility.

Original languageEnglish (US)
Article number86
JournalBMC Genetics
Volume14
DOIs
StatePublished - Sep 22 2013
Externally publishedYes

Fingerprint

Type 2 Diabetes Mellitus
Obesity
Fats
Genes
Body Mass Index
Odds Ratio
Confidence Intervals
Genome-Wide Association Study
Genetic Markers
Meta-Analysis
Case-Control Studies
Logistic Models
Alleles
Population

Keywords

  • Fat mass and obesity-associated Gene
  • Genetic susceptibility
  • Genome-wide association study
  • Single nucleotide polymorphism
  • Type 2 diabetes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Genetic variant in fat mass and obesity-associated gene associated with type 2 diabetes risk in han chinese. / Qian, Yun; Liu, Sijun; Lu, Feng; Li, Huizhang; Dong, Meihua; Lin, Yudi; Du, Jiangbo; Lin, Yuan; Gong, Jianhang; Jin, Guangfu; Dai, Juncheng; Hu, Zhibin; Shen, Hongbing.

In: BMC Genetics, Vol. 14, 86, 22.09.2013.

Research output: Contribution to journalArticle

Qian, Y, Liu, S, Lu, F, Li, H, Dong, M, Lin, Y, Du, J, Lin, Y, Gong, J, Jin, G, Dai, J, Hu, Z & Shen, H 2013, 'Genetic variant in fat mass and obesity-associated gene associated with type 2 diabetes risk in han chinese', BMC Genetics, vol. 14, 86. https://doi.org/10.1186/1471-2156-14-86
Qian, Yun ; Liu, Sijun ; Lu, Feng ; Li, Huizhang ; Dong, Meihua ; Lin, Yudi ; Du, Jiangbo ; Lin, Yuan ; Gong, Jianhang ; Jin, Guangfu ; Dai, Juncheng ; Hu, Zhibin ; Shen, Hongbing. / Genetic variant in fat mass and obesity-associated gene associated with type 2 diabetes risk in han chinese. In: BMC Genetics. 2013 ; Vol. 14.
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abstract = "Background: Genome-wide association study (GWAS) has identified that rs8050136 C/A polymorphism in fat mass and obesity-associated gene (FTO) was associated with the risk of type 2 diabetes (T2D) in Europeans. But this association was abolished after adjustment for body mass index (BMI), suggesting that the effect of rs8050136 on T2D risk might be mediated by BMI in Europeans. However, the findings in subsequent studies were inconsistent among Asian populations. To determine whether rs8050136 polymorphism in FTO is independently associated with the risk of T2D in Chinese, we conducted a case-control study with 2,925 T2D patients and 3,281 controls in Han Chinese.Results: Logistic regression revealed that the A allele of rs8050136 was significantly associated with an increased risk of T2D, independent of BMI (odds ratio (OR) = 1.17, 95{\%} confidence interval (95{\%} CI) = 1.03-1.32, p = 0.016). Meta-analysis containing 10 reported studies and our data with a total of 15,819 cases and 18,314 controls further confirmed the association between rs8050136 polymorphism and T2D risk in East Asians (OR = 1.13, 95{\%} CI = 1.07-1.19).Conclusions: Our findings indicate that the genetic variant in FTO may contribute to T2D risk in Han Chinese and rs8050136 polymorphism may be a genetic marker for T2D susceptibility.",
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T1 - Genetic variant in fat mass and obesity-associated gene associated with type 2 diabetes risk in han chinese

AU - Qian, Yun

AU - Liu, Sijun

AU - Lu, Feng

AU - Li, Huizhang

AU - Dong, Meihua

AU - Lin, Yudi

AU - Du, Jiangbo

AU - Lin, Yuan

AU - Gong, Jianhang

AU - Jin, Guangfu

AU - Dai, Juncheng

AU - Hu, Zhibin

AU - Shen, Hongbing

PY - 2013/9/22

Y1 - 2013/9/22

N2 - Background: Genome-wide association study (GWAS) has identified that rs8050136 C/A polymorphism in fat mass and obesity-associated gene (FTO) was associated with the risk of type 2 diabetes (T2D) in Europeans. But this association was abolished after adjustment for body mass index (BMI), suggesting that the effect of rs8050136 on T2D risk might be mediated by BMI in Europeans. However, the findings in subsequent studies were inconsistent among Asian populations. To determine whether rs8050136 polymorphism in FTO is independently associated with the risk of T2D in Chinese, we conducted a case-control study with 2,925 T2D patients and 3,281 controls in Han Chinese.Results: Logistic regression revealed that the A allele of rs8050136 was significantly associated with an increased risk of T2D, independent of BMI (odds ratio (OR) = 1.17, 95% confidence interval (95% CI) = 1.03-1.32, p = 0.016). Meta-analysis containing 10 reported studies and our data with a total of 15,819 cases and 18,314 controls further confirmed the association between rs8050136 polymorphism and T2D risk in East Asians (OR = 1.13, 95% CI = 1.07-1.19).Conclusions: Our findings indicate that the genetic variant in FTO may contribute to T2D risk in Han Chinese and rs8050136 polymorphism may be a genetic marker for T2D susceptibility.

AB - Background: Genome-wide association study (GWAS) has identified that rs8050136 C/A polymorphism in fat mass and obesity-associated gene (FTO) was associated with the risk of type 2 diabetes (T2D) in Europeans. But this association was abolished after adjustment for body mass index (BMI), suggesting that the effect of rs8050136 on T2D risk might be mediated by BMI in Europeans. However, the findings in subsequent studies were inconsistent among Asian populations. To determine whether rs8050136 polymorphism in FTO is independently associated with the risk of T2D in Chinese, we conducted a case-control study with 2,925 T2D patients and 3,281 controls in Han Chinese.Results: Logistic regression revealed that the A allele of rs8050136 was significantly associated with an increased risk of T2D, independent of BMI (odds ratio (OR) = 1.17, 95% confidence interval (95% CI) = 1.03-1.32, p = 0.016). Meta-analysis containing 10 reported studies and our data with a total of 15,819 cases and 18,314 controls further confirmed the association between rs8050136 polymorphism and T2D risk in East Asians (OR = 1.13, 95% CI = 1.07-1.19).Conclusions: Our findings indicate that the genetic variant in FTO may contribute to T2D risk in Han Chinese and rs8050136 polymorphism may be a genetic marker for T2D susceptibility.

KW - Fat mass and obesity-associated Gene

KW - Genetic susceptibility

KW - Genome-wide association study

KW - Single nucleotide polymorphism

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