Genetic variants at 10p11 confer risk of tetralogy of fallot in Chinese of Nanjing

Jing Xu, Yuan Lin, Linjie Si, Guangfu Jin, Juncheng Dai, Cheng Wang, Jiaping Chen, Min Da, Yuanli Hu, Chenlong Yi, Zhibin Hu, Hongbing Shen, Xuming Mo, Yijiang Chen, Xiaowei Wang

Research output: Contribution to journalArticle

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Abstract

A recent genome-wide association study (GWAS) has identified a new subset of susceptibility loci of Tetralogy of Fallot (TOF), one form of cyanotic congenital heart disease (CHD), on chromosomes 10p11, 10p14, 12q24, 13q31, 15q13 and 16q12 in Europeans. In the current study, we conducted a case-control study in a Chinese population including 1,010 CHD cases [atrial septal defect (ASD), ventricular septal defect (VSD) and TOF] and 1,962 controls to evaluate the associations of these loci with risk of CHD. We found that rs2228638 in NRP1 on 10p11 was significantly increased the risk of TOF (OR = 1.52, 95% CI = 1.13-2.04, P = 0.006), but not in other subgroups including ASD and VSD. In addition, no significant associations were observed between the other loci and the risk of ASD, VSD or TOF. Our results suggested that the genetic variants on 10p11 may serve as candidate markers for TOF susceptibility in Chinese population.

Original languageEnglish (US)
Article numbere89636
JournalPLoS One
Volume9
Issue number3
DOIs
StatePublished - Mar 3 2014
Externally publishedYes

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Tetralogy of Fallot
heart diseases
Atrial Heart Septal Defects
Ventricular Heart Septal Defects
Defects
loci
Heart Diseases
case-control studies
Genome-Wide Association Study
chromosomes
Population
Case-Control Studies
Chromosomes
Genes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Genetic variants at 10p11 confer risk of tetralogy of fallot in Chinese of Nanjing. / Xu, Jing; Lin, Yuan; Si, Linjie; Jin, Guangfu; Dai, Juncheng; Wang, Cheng; Chen, Jiaping; Da, Min; Hu, Yuanli; Yi, Chenlong; Hu, Zhibin; Shen, Hongbing; Mo, Xuming; Chen, Yijiang; Wang, Xiaowei.

In: PLoS One, Vol. 9, No. 3, e89636, 03.03.2014.

Research output: Contribution to journalArticle

Xu, J, Lin, Y, Si, L, Jin, G, Dai, J, Wang, C, Chen, J, Da, M, Hu, Y, Yi, C, Hu, Z, Shen, H, Mo, X, Chen, Y & Wang, X 2014, 'Genetic variants at 10p11 confer risk of tetralogy of fallot in Chinese of Nanjing', PLoS One, vol. 9, no. 3, e89636. https://doi.org/10.1371/journal.pone.0089636
Xu, Jing ; Lin, Yuan ; Si, Linjie ; Jin, Guangfu ; Dai, Juncheng ; Wang, Cheng ; Chen, Jiaping ; Da, Min ; Hu, Yuanli ; Yi, Chenlong ; Hu, Zhibin ; Shen, Hongbing ; Mo, Xuming ; Chen, Yijiang ; Wang, Xiaowei. / Genetic variants at 10p11 confer risk of tetralogy of fallot in Chinese of Nanjing. In: PLoS One. 2014 ; Vol. 9, No. 3.
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abstract = "A recent genome-wide association study (GWAS) has identified a new subset of susceptibility loci of Tetralogy of Fallot (TOF), one form of cyanotic congenital heart disease (CHD), on chromosomes 10p11, 10p14, 12q24, 13q31, 15q13 and 16q12 in Europeans. In the current study, we conducted a case-control study in a Chinese population including 1,010 CHD cases [atrial septal defect (ASD), ventricular septal defect (VSD) and TOF] and 1,962 controls to evaluate the associations of these loci with risk of CHD. We found that rs2228638 in NRP1 on 10p11 was significantly increased the risk of TOF (OR = 1.52, 95{\%} CI = 1.13-2.04, P = 0.006), but not in other subgroups including ASD and VSD. In addition, no significant associations were observed between the other loci and the risk of ASD, VSD or TOF. Our results suggested that the genetic variants on 10p11 may serve as candidate markers for TOF susceptibility in Chinese population.",
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AU - Jin, Guangfu

AU - Dai, Juncheng

AU - Wang, Cheng

AU - Chen, Jiaping

AU - Da, Min

AU - Hu, Yuanli

AU - Yi, Chenlong

AU - Hu, Zhibin

AU - Shen, Hongbing

AU - Mo, Xuming

AU - Chen, Yijiang

AU - Wang, Xiaowei

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