Genetic Variants in WNT2B and BTRC Predict Melanoma Survival

Qiong Shi, Hongliang Liu, Peng Han, Chunying Li, Yanru Wang, Wenting Wu, Dakai Zhu, Christopher I. Amos, Shenying Fang, Jeffrey E. Lee, Jiali Han, Qingyi Wei

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cutaneous melanoma (CM) is the most lethal skin cancer. The Wnt pathway has an impact on development, invasion, and metastasis of CM, thus likely affecting CM prognosis. Using data from a published genome-wide association study from The University of Texas MD Anderson Cancer Center, we assessed the associations of 19,830 common single-nucleotide polymorphisms (SNPs) in 151 Wnt pathway autosomal genes with CM-specific survival and then validated significant SNPs in another genome-wide association study from Harvard University. In the single-locus analysis, 1,855 SNPs were significantly associated with CM-specific survival at P < 0.05, of which 547 SNPs were still considered noteworthy after the correction by the false-positive report probability. In the replication, two SNPs remained significantly associated with CM-specific survival after multiple comparison correction. By performing functional prediction and stepwise selection, we identified two independent SNPs (i.e., WNT2B rs1175649 G>T and BTRC rs61873997 G>A) that showed a predictive role in CM-specific survival, with an effect-allele-attributed hazards ratio (adjusted hazards ratio) of 1.99 (95% confidence interval = 1.41–2.81, P = 8.10 × 10−5) and 0.61 (0.46–0.80, 3.12×10−4), respectively. Collectively, these variants in the Wnt pathway genes may be biomarkers for outcomes of patients with CM, if validated by larger studies.

Original languageEnglish (US)
Pages (from-to)1749-1756
Number of pages8
JournalJournal of Investigative Dermatology
Volume137
Issue number8
DOIs
StatePublished - Aug 1 2017

Fingerprint

Melanoma
Genes
Polymorphism
Skin
Survival
Nucleotides
Wnt Signaling Pathway
Hazards
Single Nucleotide Polymorphism
Association reactions
Genome-Wide Association Study
Biomarkers
Skin Neoplasms
Alleles
Confidence Intervals
Neoplasm Metastasis
Neoplasms

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

Shi, Q., Liu, H., Han, P., Li, C., Wang, Y., Wu, W., ... Wei, Q. (2017). Genetic Variants in WNT2B and BTRC Predict Melanoma Survival. Journal of Investigative Dermatology, 137(8), 1749-1756. https://doi.org/10.1016/j.jid.2017.04.023

Genetic Variants in WNT2B and BTRC Predict Melanoma Survival. / Shi, Qiong; Liu, Hongliang; Han, Peng; Li, Chunying; Wang, Yanru; Wu, Wenting; Zhu, Dakai; Amos, Christopher I.; Fang, Shenying; Lee, Jeffrey E.; Han, Jiali; Wei, Qingyi.

In: Journal of Investigative Dermatology, Vol. 137, No. 8, 01.08.2017, p. 1749-1756.

Research output: Contribution to journalArticle

Shi, Q, Liu, H, Han, P, Li, C, Wang, Y, Wu, W, Zhu, D, Amos, CI, Fang, S, Lee, JE, Han, J & Wei, Q 2017, 'Genetic Variants in WNT2B and BTRC Predict Melanoma Survival', Journal of Investigative Dermatology, vol. 137, no. 8, pp. 1749-1756. https://doi.org/10.1016/j.jid.2017.04.023
Shi, Qiong ; Liu, Hongliang ; Han, Peng ; Li, Chunying ; Wang, Yanru ; Wu, Wenting ; Zhu, Dakai ; Amos, Christopher I. ; Fang, Shenying ; Lee, Jeffrey E. ; Han, Jiali ; Wei, Qingyi. / Genetic Variants in WNT2B and BTRC Predict Melanoma Survival. In: Journal of Investigative Dermatology. 2017 ; Vol. 137, No. 8. pp. 1749-1756.
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