Genetic variation in XPD, sun exposure, and risk of skin cancer

Jiali Han, Graham A. Colditz, Jun S. Liu, David J. Hunter

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

The XPD gene is involved in the nucleotide excision repair pathway removing DNA photoproducts induced by UV radiation. Genetic variation in XPD may exert a subtle effect on DNA repair capacity. We assessed the associations between two common nonsynonymous polymorphisms (Asp312Asn and LyS 751Gln) with skin cancer risk in a nested case-control study within the Nurses' Health Study (219 melanoma, 286 squamous cell carcinoma, 300 basal cell carcinoma, and 874 controls) along with exploratory analysis on the haplotype structure of the XPD gene. There were inverse associations between the LyS751Gln and Asp312Asn polymorphisms and the risks of melanoma and squamous cell carcinoma. No association was observed between these two polymorphisms and basal cell carcinoma risk. We also observed that the association of the 751Gln allele with melanoma risk was modified by lifetime severe sunburns, cumulative sun exposure with a bathing suit, and constitutional susceptibility score (P for interaction = 0.03, 0.04, and 0.02 respectively). Similar interactions were also observed for the Asp Asn. Our data suggest these two XPD nonsynonymous polymorphisms may be associated with skin cancer risk, especially for melanoma.

Original languageEnglish (US)
Pages (from-to)1539-1544
Number of pages6
JournalCancer Epidemiology Biomarkers and Prevention
Volume14
Issue number6
DOIs
StatePublished - Jun 1 2005
Externally publishedYes

Fingerprint

Skin Neoplasms
Solar System
Melanoma
Basal Cell Carcinoma
DNA Repair
Squamous Cell Carcinoma
Sunburn
Viperidae
Haplotypes
Genes
Case-Control Studies
Alleles
Nurses
Radiation
DNA
Health

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Genetic variation in XPD, sun exposure, and risk of skin cancer. / Han, Jiali; Colditz, Graham A.; Liu, Jun S.; Hunter, David J.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 14, No. 6, 01.06.2005, p. 1539-1544.

Research output: Contribution to journalArticle

Han, Jiali ; Colditz, Graham A. ; Liu, Jun S. ; Hunter, David J. / Genetic variation in XPD, sun exposure, and risk of skin cancer. In: Cancer Epidemiology Biomarkers and Prevention. 2005 ; Vol. 14, No. 6. pp. 1539-1544.
@article{af32f507ebb94b478e4e6272ac6b3f82,
title = "Genetic variation in XPD, sun exposure, and risk of skin cancer",
abstract = "The XPD gene is involved in the nucleotide excision repair pathway removing DNA photoproducts induced by UV radiation. Genetic variation in XPD may exert a subtle effect on DNA repair capacity. We assessed the associations between two common nonsynonymous polymorphisms (Asp312Asn and LyS 751Gln) with skin cancer risk in a nested case-control study within the Nurses' Health Study (219 melanoma, 286 squamous cell carcinoma, 300 basal cell carcinoma, and 874 controls) along with exploratory analysis on the haplotype structure of the XPD gene. There were inverse associations between the LyS751Gln and Asp312Asn polymorphisms and the risks of melanoma and squamous cell carcinoma. No association was observed between these two polymorphisms and basal cell carcinoma risk. We also observed that the association of the 751Gln allele with melanoma risk was modified by lifetime severe sunburns, cumulative sun exposure with a bathing suit, and constitutional susceptibility score (P for interaction = 0.03, 0.04, and 0.02 respectively). Similar interactions were also observed for the Asp Asn. Our data suggest these two XPD nonsynonymous polymorphisms may be associated with skin cancer risk, especially for melanoma.",
author = "Jiali Han and Colditz, {Graham A.} and Liu, {Jun S.} and Hunter, {David J.}",
year = "2005",
month = "6",
day = "1",
doi = "10.1158/1055-9965.EPI-04-0846",
language = "English (US)",
volume = "14",
pages = "1539--1544",
journal = "Cancer Epidemiology Biomarkers and Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",
number = "6",

}

TY - JOUR

T1 - Genetic variation in XPD, sun exposure, and risk of skin cancer

AU - Han, Jiali

AU - Colditz, Graham A.

AU - Liu, Jun S.

AU - Hunter, David J.

PY - 2005/6/1

Y1 - 2005/6/1

N2 - The XPD gene is involved in the nucleotide excision repair pathway removing DNA photoproducts induced by UV radiation. Genetic variation in XPD may exert a subtle effect on DNA repair capacity. We assessed the associations between two common nonsynonymous polymorphisms (Asp312Asn and LyS 751Gln) with skin cancer risk in a nested case-control study within the Nurses' Health Study (219 melanoma, 286 squamous cell carcinoma, 300 basal cell carcinoma, and 874 controls) along with exploratory analysis on the haplotype structure of the XPD gene. There were inverse associations between the LyS751Gln and Asp312Asn polymorphisms and the risks of melanoma and squamous cell carcinoma. No association was observed between these two polymorphisms and basal cell carcinoma risk. We also observed that the association of the 751Gln allele with melanoma risk was modified by lifetime severe sunburns, cumulative sun exposure with a bathing suit, and constitutional susceptibility score (P for interaction = 0.03, 0.04, and 0.02 respectively). Similar interactions were also observed for the Asp Asn. Our data suggest these two XPD nonsynonymous polymorphisms may be associated with skin cancer risk, especially for melanoma.

AB - The XPD gene is involved in the nucleotide excision repair pathway removing DNA photoproducts induced by UV radiation. Genetic variation in XPD may exert a subtle effect on DNA repair capacity. We assessed the associations between two common nonsynonymous polymorphisms (Asp312Asn and LyS 751Gln) with skin cancer risk in a nested case-control study within the Nurses' Health Study (219 melanoma, 286 squamous cell carcinoma, 300 basal cell carcinoma, and 874 controls) along with exploratory analysis on the haplotype structure of the XPD gene. There were inverse associations between the LyS751Gln and Asp312Asn polymorphisms and the risks of melanoma and squamous cell carcinoma. No association was observed between these two polymorphisms and basal cell carcinoma risk. We also observed that the association of the 751Gln allele with melanoma risk was modified by lifetime severe sunburns, cumulative sun exposure with a bathing suit, and constitutional susceptibility score (P for interaction = 0.03, 0.04, and 0.02 respectively). Similar interactions were also observed for the Asp Asn. Our data suggest these two XPD nonsynonymous polymorphisms may be associated with skin cancer risk, especially for melanoma.

UR - http://www.scopus.com/inward/record.url?scp=20444400600&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20444400600&partnerID=8YFLogxK

U2 - 10.1158/1055-9965.EPI-04-0846

DO - 10.1158/1055-9965.EPI-04-0846

M3 - Article

C2 - 15941969

AN - SCOPUS:20444400600

VL - 14

SP - 1539

EP - 1544

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

IS - 6

ER -