Genetic variation of GPLD1 associates with serum GPI-PLD levels: A preliminary study

Mark A. Deeg, Xiaoling Xuei, George Eckert, Robert V. Considine, Ying Grace Li, J. Howard Pratt

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

HDL is a heterogeneous mixture of lipoprotein particles varying in composition, size, and function. We and others have described a small (7.0 nm), minor (0.1% of total apolipoprotein AI) particle containing apolipoprotein AI, AIV and glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) in humans the function of which is not entirely known. Circulating GPI-PLD levels are regulated by multiple factors including genetics. To determine if genetic variation in GPLD1 affects circulating GPI-PLD levels, we examined the relationship between 32 SNPS upstream, within, and downstream of GPLD1 and circulating GPI-PLD levels in Caucasians (n = 77) and African-Americans (n = 99). The genotype distribution among races differed at 13 SNPs. Nine SNPS were associated with circulating GPI-PLD levels in Caucasians but not African-Americans. These results suggest that genetic variation of GPLD1 appears to associate with circulating GPI-PLD levels. This article is part of a Special Issue entitled Advances in High Density Lipoprotein Formation and Metabolism: A Tribute to John F. Oram (1945-2010).

Original languageEnglish (US)
Pages (from-to)381-385
Number of pages5
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume1821
Issue number3
DOIs
StatePublished - Mar 1 2012

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Keywords

  • Apolipoprotein AI
  • Glycosylphosphatidylinositol-phospholipase D
  • HDL

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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