Genetically determined differences in liver alcohol dehydrogenase activity in male rats

David Crabb, Ting Kai Li

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Alcohol dehydrogenase (EC 1.1.1.1) activity was measured in liver extracts from one outbred and three inbred strains of rats. Strain-specific differences in enzyme activity were observed in the adult male rats. The differences appeared as the animals reached puberty. Studies on the enzyme purified from Sprague-Dawley and ACI rats indicate that the enzymes in these strains are identical and that the difference in activity found in liver extracts is due to differences in the amount of enzyme present. Genetic crosses between Sprague-Dawley and ACI rats suggest that the liver content of alcohol dehydrogenase is controlled by an autosomal regulatory locus with the characteristics of a temporal gene.

Original languageEnglish
Pages (from-to)987-996
Number of pages10
JournalBiochemical Genetics
Volume23
Issue number11-12
DOIs
StatePublished - Dec 1985

Fingerprint

Alcohol Dehydrogenase
alcohol dehydrogenase
Liver
Rats
alcohol
Inbred ACI Rats
enzyme
Liver Extracts
liver
rats
Enzymes
Sprague Dawley Rats
enzymes
Genetic Crosses
Inbred Strains Rats
enzyme activity
extracts
Enzyme activity
puberty
Puberty

Keywords

  • alcohol dehydrogenase
  • gene expression
  • temporal genes

ASJC Scopus subject areas

  • Genetics
  • Biochemistry

Cite this

Genetically determined differences in liver alcohol dehydrogenase activity in male rats. / Crabb, David; Li, Ting Kai.

In: Biochemical Genetics, Vol. 23, No. 11-12, 12.1985, p. 987-996.

Research output: Contribution to journalArticle

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