Genetics and alcoholism

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Alcohol is widely consumed; however, excessive use creates serious physical, psychological and social problems and contributes to the pathogenesis of many diseases. Alcohol use disorders (that is, alcohol dependence and alcohol abuse) are maladaptive patterns of excessive drinking that lead to serious problems. Abundant evidence indicates that alcohol dependence (alcoholism) is a complex genetic disease, with variations in a large number of genes affecting a person's risk of alcoholism. Some of these genes have been identified, including two genes involved in the metabolism of alcohol (ADH1B and ALDH2) that have the strongest known affects on the risk of alcoholism. Studies continue to reveal other genes in which variants affect the risk of alcoholism or related traits, including GABRA2, CHRM2, KCNJ6 and AUTS2. As more variants are analysed and studies are combined for meta-analysis to achieve increased sample sizes, an improved picture of the many genes and pathways that affect the risk of alcoholism will be possible.

Original languageEnglish
Pages (from-to)487-494
Number of pages8
JournalNature Reviews Gastroenterology and Hepatology
Volume10
Issue number8
DOIs
StatePublished - Aug 2013

Fingerprint

Alcoholism
Genes
Alcohols
Inborn Genetic Diseases
Social Problems
Sample Size
Drinking
Meta-Analysis
Psychology

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Genetics and alcoholism. / Edenberg, Howard; Foroud, Tatiana.

In: Nature Reviews Gastroenterology and Hepatology, Vol. 10, No. 8, 08.2013, p. 487-494.

Research output: Contribution to journalArticle

@article{35c0080605f54562b9632202a1945c83,
title = "Genetics and alcoholism",
abstract = "Alcohol is widely consumed; however, excessive use creates serious physical, psychological and social problems and contributes to the pathogenesis of many diseases. Alcohol use disorders (that is, alcohol dependence and alcohol abuse) are maladaptive patterns of excessive drinking that lead to serious problems. Abundant evidence indicates that alcohol dependence (alcoholism) is a complex genetic disease, with variations in a large number of genes affecting a person's risk of alcoholism. Some of these genes have been identified, including two genes involved in the metabolism of alcohol (ADH1B and ALDH2) that have the strongest known affects on the risk of alcoholism. Studies continue to reveal other genes in which variants affect the risk of alcoholism or related traits, including GABRA2, CHRM2, KCNJ6 and AUTS2. As more variants are analysed and studies are combined for meta-analysis to achieve increased sample sizes, an improved picture of the many genes and pathways that affect the risk of alcoholism will be possible.",
author = "Howard Edenberg and Tatiana Foroud",
year = "2013",
month = "8",
doi = "10.1038/nrgastro.2013.86",
language = "English",
volume = "10",
pages = "487--494",
journal = "Nature Reviews Gastroenterology and Hepatology",
issn = "1759-5045",
publisher = "Nature Publishing Group",
number = "8",

}

TY - JOUR

T1 - Genetics and alcoholism

AU - Edenberg, Howard

AU - Foroud, Tatiana

PY - 2013/8

Y1 - 2013/8

N2 - Alcohol is widely consumed; however, excessive use creates serious physical, psychological and social problems and contributes to the pathogenesis of many diseases. Alcohol use disorders (that is, alcohol dependence and alcohol abuse) are maladaptive patterns of excessive drinking that lead to serious problems. Abundant evidence indicates that alcohol dependence (alcoholism) is a complex genetic disease, with variations in a large number of genes affecting a person's risk of alcoholism. Some of these genes have been identified, including two genes involved in the metabolism of alcohol (ADH1B and ALDH2) that have the strongest known affects on the risk of alcoholism. Studies continue to reveal other genes in which variants affect the risk of alcoholism or related traits, including GABRA2, CHRM2, KCNJ6 and AUTS2. As more variants are analysed and studies are combined for meta-analysis to achieve increased sample sizes, an improved picture of the many genes and pathways that affect the risk of alcoholism will be possible.

AB - Alcohol is widely consumed; however, excessive use creates serious physical, psychological and social problems and contributes to the pathogenesis of many diseases. Alcohol use disorders (that is, alcohol dependence and alcohol abuse) are maladaptive patterns of excessive drinking that lead to serious problems. Abundant evidence indicates that alcohol dependence (alcoholism) is a complex genetic disease, with variations in a large number of genes affecting a person's risk of alcoholism. Some of these genes have been identified, including two genes involved in the metabolism of alcohol (ADH1B and ALDH2) that have the strongest known affects on the risk of alcoholism. Studies continue to reveal other genes in which variants affect the risk of alcoholism or related traits, including GABRA2, CHRM2, KCNJ6 and AUTS2. As more variants are analysed and studies are combined for meta-analysis to achieve increased sample sizes, an improved picture of the many genes and pathways that affect the risk of alcoholism will be possible.

UR - http://www.scopus.com/inward/record.url?scp=84881475110&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881475110&partnerID=8YFLogxK

U2 - 10.1038/nrgastro.2013.86

DO - 10.1038/nrgastro.2013.86

M3 - Article

C2 - 23712313

AN - SCOPUS:84881475110

VL - 10

SP - 487

EP - 494

JO - Nature Reviews Gastroenterology and Hepatology

JF - Nature Reviews Gastroenterology and Hepatology

SN - 1759-5045

IS - 8

ER -