Genetics of Alcoholism

Howard Edenberg, Joel Gelernter, Arpana Agrawal

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Purpose of Review: We review the search for genetic variants that affect the risk for alcohol dependence and alcohol consumption. Recent Findings: Variations in genes affecting alcohol metabolism (ADH1B, ALDH2) are protective against both alcohol dependence and excessive consumption, but different variants are found in different populations. There are different patterns of risk variants for alcohol dependence vs. consumption. Variants for alcohol dependence, but not consumption, are associated with risk for other psychiatric illnesses. Summary: ADH1B and ALDH2 strongly affect both consumption and dependence. Variations in many other genes affect both consumption and dependence—or one or the other of these traits—but individual effect sizes are small. Evidence for other specific genes that affect dependence is not yet strong. Most current knowledge derives from studies of European-ancestry populations, and large studies of carefully phenotyped subjects from different populations are needed to understand the genetic contributions to alcohol consumption and alcohol use disorders.

Original languageEnglish (US)
Article number26
JournalCurrent psychiatry reports
Volume21
Issue number4
DOIs
StatePublished - Apr 1 2019

Fingerprint

Alcoholism
Alcohol Drinking
Alcohols
Population
Genes
Psychiatry

Keywords

  • Alcohol dehydrogenase
  • Alcohol dependence
  • Alcoholism
  • Drinking
  • Genetics
  • GWAS

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Genetics of Alcoholism. / Edenberg, Howard; Gelernter, Joel; Agrawal, Arpana.

In: Current psychiatry reports, Vol. 21, No. 4, 26, 01.04.2019.

Research output: Contribution to journalReview article

Edenberg, Howard ; Gelernter, Joel ; Agrawal, Arpana. / Genetics of Alcoholism. In: Current psychiatry reports. 2019 ; Vol. 21, No. 4.
@article{13d9e21e05a0491883bd6e49666a704d,
title = "Genetics of Alcoholism",
abstract = "Purpose of Review: We review the search for genetic variants that affect the risk for alcohol dependence and alcohol consumption. Recent Findings: Variations in genes affecting alcohol metabolism (ADH1B, ALDH2) are protective against both alcohol dependence and excessive consumption, but different variants are found in different populations. There are different patterns of risk variants for alcohol dependence vs. consumption. Variants for alcohol dependence, but not consumption, are associated with risk for other psychiatric illnesses. Summary: ADH1B and ALDH2 strongly affect both consumption and dependence. Variations in many other genes affect both consumption and dependence—or one or the other of these traits—but individual effect sizes are small. Evidence for other specific genes that affect dependence is not yet strong. Most current knowledge derives from studies of European-ancestry populations, and large studies of carefully phenotyped subjects from different populations are needed to understand the genetic contributions to alcohol consumption and alcohol use disorders.",
keywords = "Alcohol dehydrogenase, Alcohol dependence, Alcoholism, Drinking, Genetics, GWAS",
author = "Howard Edenberg and Joel Gelernter and Arpana Agrawal",
year = "2019",
month = "4",
day = "1",
doi = "10.1007/s11920-019-1008-1",
language = "English (US)",
volume = "21",
journal = "Current Psychiatry Reports",
issn = "1523-3812",
publisher = "Current Science, Inc.",
number = "4",

}

TY - JOUR

T1 - Genetics of Alcoholism

AU - Edenberg, Howard

AU - Gelernter, Joel

AU - Agrawal, Arpana

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Purpose of Review: We review the search for genetic variants that affect the risk for alcohol dependence and alcohol consumption. Recent Findings: Variations in genes affecting alcohol metabolism (ADH1B, ALDH2) are protective against both alcohol dependence and excessive consumption, but different variants are found in different populations. There are different patterns of risk variants for alcohol dependence vs. consumption. Variants for alcohol dependence, but not consumption, are associated with risk for other psychiatric illnesses. Summary: ADH1B and ALDH2 strongly affect both consumption and dependence. Variations in many other genes affect both consumption and dependence—or one or the other of these traits—but individual effect sizes are small. Evidence for other specific genes that affect dependence is not yet strong. Most current knowledge derives from studies of European-ancestry populations, and large studies of carefully phenotyped subjects from different populations are needed to understand the genetic contributions to alcohol consumption and alcohol use disorders.

AB - Purpose of Review: We review the search for genetic variants that affect the risk for alcohol dependence and alcohol consumption. Recent Findings: Variations in genes affecting alcohol metabolism (ADH1B, ALDH2) are protective against both alcohol dependence and excessive consumption, but different variants are found in different populations. There are different patterns of risk variants for alcohol dependence vs. consumption. Variants for alcohol dependence, but not consumption, are associated with risk for other psychiatric illnesses. Summary: ADH1B and ALDH2 strongly affect both consumption and dependence. Variations in many other genes affect both consumption and dependence—or one or the other of these traits—but individual effect sizes are small. Evidence for other specific genes that affect dependence is not yet strong. Most current knowledge derives from studies of European-ancestry populations, and large studies of carefully phenotyped subjects from different populations are needed to understand the genetic contributions to alcohol consumption and alcohol use disorders.

KW - Alcohol dehydrogenase

KW - Alcohol dependence

KW - Alcoholism

KW - Drinking

KW - Genetics

KW - GWAS

UR - http://www.scopus.com/inward/record.url?scp=85062597575&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062597575&partnerID=8YFLogxK

U2 - 10.1007/s11920-019-1008-1

DO - 10.1007/s11920-019-1008-1

M3 - Review article

C2 - 30852706

AN - SCOPUS:85062597575

VL - 21

JO - Current Psychiatry Reports

JF - Current Psychiatry Reports

SN - 1523-3812

IS - 4

M1 - 26

ER -