Abstract
There is substantial evidence for a significant genetic component to the risk of alcoholism. In searching for genes that contribute to this risk, several approaches may be utilized in order to identify the genetic loci underlying alcoholism susceptibility. Several candidate genes have been evaluated for their role in alcoholism; however, with the exception of the enzymes of alcohol metabolism, results from these studies have been inconsistent. Recently, two large studies have employed a genome screen methodology to identify novel genes contributing to the risk of alcoholism. As an alternative strategy, researchers have utilized mouse and rat models to identify quantitative trait loci influencing alcohol preference. Through the development of congenic lines and transgenic and knock-out animals, candidate genes can be identified and evaluated for their role in alcohol preference.
| Original language | English |
|---|---|
| Pages (from-to) | 261-278 |
| Number of pages | 18 |
| Journal | American Journal on Addictions |
| Volume | 8 |
| Issue number | 4 |
| DOIs | |
| State | Published - Sep 1999 |
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ASJC Scopus subject areas
- Medicine (miscellaneous)
Cite this
Genetics of alcoholism : A review of recent studies in human and animal models. / Foroud, Tatiana; Li, Ting Kai.
In: American Journal on Addictions, Vol. 8, No. 4, 09.1999, p. 261-278.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genetics of alcoholism
T2 - A review of recent studies in human and animal models
AU - Foroud, Tatiana
AU - Li, Ting Kai
PY - 1999/9
Y1 - 1999/9
N2 - There is substantial evidence for a significant genetic component to the risk of alcoholism. In searching for genes that contribute to this risk, several approaches may be utilized in order to identify the genetic loci underlying alcoholism susceptibility. Several candidate genes have been evaluated for their role in alcoholism; however, with the exception of the enzymes of alcohol metabolism, results from these studies have been inconsistent. Recently, two large studies have employed a genome screen methodology to identify novel genes contributing to the risk of alcoholism. As an alternative strategy, researchers have utilized mouse and rat models to identify quantitative trait loci influencing alcohol preference. Through the development of congenic lines and transgenic and knock-out animals, candidate genes can be identified and evaluated for their role in alcohol preference.
AB - There is substantial evidence for a significant genetic component to the risk of alcoholism. In searching for genes that contribute to this risk, several approaches may be utilized in order to identify the genetic loci underlying alcoholism susceptibility. Several candidate genes have been evaluated for their role in alcoholism; however, with the exception of the enzymes of alcohol metabolism, results from these studies have been inconsistent. Recently, two large studies have employed a genome screen methodology to identify novel genes contributing to the risk of alcoholism. As an alternative strategy, researchers have utilized mouse and rat models to identify quantitative trait loci influencing alcohol preference. Through the development of congenic lines and transgenic and knock-out animals, candidate genes can be identified and evaluated for their role in alcohol preference.
UR - http://www.scopus.com/inward/record.url?scp=0032736548&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032736548&partnerID=8YFLogxK
U2 - 10.1080/105504999305677
DO - 10.1080/105504999305677
M3 - Article
C2 - 10598210
AN - SCOPUS:0032736548
VL - 8
SP - 261
EP - 278
JO - American Journal on Addictions
JF - American Journal on Addictions
SN - 1055-0496
IS - 4
ER -