Genetics of comorbid mood disorder and alcohol dependence

John I. Nurnberger, Samuel Kuperman, Leah Flury-Wetherill, Eric T. Meyer, William B. Lawson, Dean F. MacKinnon

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Objectives: To assess genetic vulnerability factors related to comorbid mood disorder and alcohol dependence. Methods: We analyzed family studies of bipolar affective disorder for familiality of comorbid alcohol dependence. We then analyzed family studies of alcohol dependence for familiality (and genetic linkage characteristics) of comorbid depression and mania. Results: Alcohol dependence was increased in subjects with mood disorder diagnoses within a series of families ascertained for bipolar illness. Comorbid alcohol dependence was found to be familial (Relative Risk = 1.5, p <.002). Similarly, comorbid depression and mania are familial within a series of families ascertained for alcohol dependence. Alcohol dependence and depression appear to be linked to markers on chromosome 1p; they are also associated with the gene coding for the M2 muscarinic receptor on chromosome 7q (CHRM2). Conclusions: There are specific genetic vulnerability factors related to comorbid alcohol dependence and depression. Family studies suggest that such specific factors may also be identified for alcohol dependence and mania.

Original languageEnglish (US)
Pages (from-to)31-46
Number of pages16
JournalJournal of Dual Diagnosis
Volume3
Issue number2
DOIs
StatePublished - Mar 22 2007

Keywords

  • Alcohol dependence
  • Bipolar affective disorder
  • Co-aggregation
  • Comorbidity
  • Genetics

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Nurnberger, J. I., Kuperman, S., Flury-Wetherill, L., Meyer, E. T., Lawson, W. B., & MacKinnon, D. F. (2007). Genetics of comorbid mood disorder and alcohol dependence. Journal of Dual Diagnosis, 3(2), 31-46. https://doi.org/10.1300/J374v03n02_05