Genetics of comorbid mood disorder and alcohol dependence

John Nurnberger, Samuel Kuperman, Leah Flury-Wetherill, Eric T. Meyer, William B. Lawson, Dean F. MacKinnon

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objectives: To assess genetic vulnerability factors related to comorbid mood disorder and alcohol dependence. Methods: We analyzed family studies of bipolar affective disorder for familiality of comorbid alcohol dependence. We then analyzed family studies of alcohol dependence for familiality (and genetic linkage characteristics) of comorbid depression and mania. Results: Alcohol dependence was increased in subjects with mood disorder diagnoses within a series of families ascertained for bipolar illness. Comorbid alcohol dependence was found to be familial (Relative Risk = 1.5, p <.002). Similarly, comorbid depression and mania are familial within a series of families ascertained for alcohol dependence. Alcohol dependence and depression appear to be linked to markers on chromosome 1p; they are also associated with the gene coding for the M2 muscarinic receptor on chromosome 7q (CHRM2). Conclusions: There are specific genetic vulnerability factors related to comorbid alcohol dependence and depression. Family studies suggest that such specific factors may also be identified for alcohol dependence and mania.

Original languageEnglish
Pages (from-to)31-46
Number of pages16
JournalJournal of Dual Diagnosis
Volume3
Issue number2
DOIs
StatePublished - Mar 22 2007

Fingerprint

Mood Disorders
Alcoholism
Bipolar Disorder
Depression
Muscarinic M2 Receptors
Genetic Linkage
Genetic Markers
Chromosomes
Genes

Keywords

  • Alcohol dependence
  • Bipolar affective disorder
  • Co-aggregation
  • Comorbidity
  • Genetics

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Nurnberger, J., Kuperman, S., Flury-Wetherill, L., Meyer, E. T., Lawson, W. B., & MacKinnon, D. F. (2007). Genetics of comorbid mood disorder and alcohol dependence. Journal of Dual Diagnosis, 3(2), 31-46. https://doi.org/10.1300/J374v03n02_05

Genetics of comorbid mood disorder and alcohol dependence. / Nurnberger, John; Kuperman, Samuel; Flury-Wetherill, Leah; Meyer, Eric T.; Lawson, William B.; MacKinnon, Dean F.

In: Journal of Dual Diagnosis, Vol. 3, No. 2, 22.03.2007, p. 31-46.

Research output: Contribution to journalArticle

Nurnberger, J, Kuperman, S, Flury-Wetherill, L, Meyer, ET, Lawson, WB & MacKinnon, DF 2007, 'Genetics of comorbid mood disorder and alcohol dependence', Journal of Dual Diagnosis, vol. 3, no. 2, pp. 31-46. https://doi.org/10.1300/J374v03n02_05
Nurnberger J, Kuperman S, Flury-Wetherill L, Meyer ET, Lawson WB, MacKinnon DF. Genetics of comorbid mood disorder and alcohol dependence. Journal of Dual Diagnosis. 2007 Mar 22;3(2):31-46. https://doi.org/10.1300/J374v03n02_05
Nurnberger, John ; Kuperman, Samuel ; Flury-Wetherill, Leah ; Meyer, Eric T. ; Lawson, William B. ; MacKinnon, Dean F. / Genetics of comorbid mood disorder and alcohol dependence. In: Journal of Dual Diagnosis. 2007 ; Vol. 3, No. 2. pp. 31-46.
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