Genetics of event-related brain potentials in response to a semantic priming paradigm in families with a history of alcoholism

L. Almasy, B. Porjesz, J. Blangero, A. Goate, Howard Edenberg, Sean O'Connor, S. Kuperman, S. J. O'Connor, J. Rohrbaugh, L. O. Bauer, T. Foroud, J. P. Rice, T. Reich, H. Begleiter

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Abstract

Event-related brain potentials (ERPs) are altered in patients with a variety of psychiatric disorders and may represent quantitative correlates of disease liability that are more amenable to genetic analysis than disease status itself. Results of a genomewide linkage screen are presented for amplitude of the N4 and P3 components of the ERP, measured at 19 scalp locations in response to a semantic priming task for 604 individuals in 100 pedigrees ascertained as part of the Collaborative Study on the Genetics of Alcoholism. N4 and P3 amplitudes in response to three: stimuli (nonwords, primed words [i.e., antonyms], and unprimed words) all showed significant heritabilities, the highest being .54. Both N4 and P3 showed significant genetic correlations across stimulus type at a given lead anti across leads within a stimulus, indicating shared genetic influences among the traits. There were also substantial genetic correlations between the N4 and P3 amplitudes for a given lead, even across stimulus type. N4 amplitudes showed suggestive evidence of linkage in several chromosomal regions, and P3 amplitudes showed significant evidence of linkage to chromosome 5 and suggestive evidence of linkage to chromosome 4.

Original languageEnglish (US)
Pages (from-to)128-135
Number of pages8
JournalAmerican Journal of Human Genetics
Volume68
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

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Evoked Potentials
Semantics
Alcoholism
Chromosomes, Human, Pair 5
Chromosomes, Human, Pair 4
Inborn Genetic Diseases
Brain
Pedigree
Scalp
Psychiatry
Lead

ASJC Scopus subject areas

  • Genetics

Cite this

Genetics of event-related brain potentials in response to a semantic priming paradigm in families with a history of alcoholism. / Almasy, L.; Porjesz, B.; Blangero, J.; Goate, A.; Edenberg, Howard; O'Connor, Sean; Kuperman, S.; O'Connor, S. J.; Rohrbaugh, J.; Bauer, L. O.; Foroud, T.; Rice, J. P.; Reich, T.; Begleiter, H.

In: American Journal of Human Genetics, Vol. 68, No. 1, 2001, p. 128-135.

Research output: Contribution to journalArticle

Almasy, L, Porjesz, B, Blangero, J, Goate, A, Edenberg, H, O'Connor, S, Kuperman, S, O'Connor, SJ, Rohrbaugh, J, Bauer, LO, Foroud, T, Rice, JP, Reich, T & Begleiter, H 2001, 'Genetics of event-related brain potentials in response to a semantic priming paradigm in families with a history of alcoholism', American Journal of Human Genetics, vol. 68, no. 1, pp. 128-135. https://doi.org/10.1086/316936
Almasy, L. ; Porjesz, B. ; Blangero, J. ; Goate, A. ; Edenberg, Howard ; O'Connor, Sean ; Kuperman, S. ; O'Connor, S. J. ; Rohrbaugh, J. ; Bauer, L. O. ; Foroud, T. ; Rice, J. P. ; Reich, T. ; Begleiter, H. / Genetics of event-related brain potentials in response to a semantic priming paradigm in families with a history of alcoholism. In: American Journal of Human Genetics. 2001 ; Vol. 68, No. 1. pp. 128-135.
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