Genetics of osteoporosis

Research output: Contribution to journalReview article

301 Citations (Scopus)

Abstract

Osteoporosis is a common multifactorial disorder of reduced bone mass. The disorder in its most common form is generalized, affecting the elderly, both sexes, and all racial groups. Multiple environmental factors are involved in the pathogenesis. Genes also play a major role as reflected by heritability of many components of bone strength. Quantitative phenotypes in bone strength in the normal population do not conform to a monogenetic mode of inheritance. The common form of osteoporosis is generally considered to be a polygenic disorder arising from the interaction of common polymorphic alleles at quantitative trait loci, with multiple environmental factors. Finding the susceptibility genes underlying osteoporosis requires identifying specific alleles that coinherit with key heritable phenotypes in bone strength. Because of the close correspondence among mammalian genomes, identification of the genes underlying bone strength in mammals such as the mouse is likely to be of major assistance in human studies. Identification of susceptibility genes for osteoporosis is one of several important approaches toward the long-term goal of understanding the molecular biology of the normal variation in bone strength and how it may be modified to prevent osteoporosis. As with all genetic studies in humans, these scientific advances will need to be made in an environment of legal and ethical safeguards that are acceptable to the general public.

Original languageEnglish (US)
Pages (from-to)303-326
Number of pages24
JournalEndocrine Reviews
Volume23
Issue number3
DOIs
StatePublished - Jan 1 2002

Fingerprint

Osteoporosis
Bone and Bones
Genes
Alleles
Phenotype
Quantitative Trait Loci
Molecular Biology
Mammals
Genome
Population

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Genetics of osteoporosis. / Peacock, Munro; Turner, Charles H.; Econs, Michael; Foroud, Tatiana.

In: Endocrine Reviews, Vol. 23, No. 3, 01.01.2002, p. 303-326.

Research output: Contribution to journalReview article

Peacock, Munro ; Turner, Charles H. ; Econs, Michael ; Foroud, Tatiana. / Genetics of osteoporosis. In: Endocrine Reviews. 2002 ; Vol. 23, No. 3. pp. 303-326.
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