Genetics of Parkinson Disease

Nathan Pankratz, Tatiana Foroud

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Parkinson disease (PD) is the second most common neurodegenerative disorder. Recent studies have consistently demonstrated that in some families, disease is attributable to a mutation in a single gene. To date, genetic analyses have detected linkage to six chromosomal regions and have identified three causative genes: PARK1 (alpha-synuclein), PARK2 (parkin), and PARK7 (DJ-1). In addition, mutations in several other genes have been implicated in familial PD. Identification of the mutations in these genes has led to the recognition that the ubiquitin-proteasome system is an important pathway that may be disrupted in PD. Studies are ongoing to identify additional genes that may contribute to PD susceptibility, particularly in late-onset families without a clear pattern of disease inheritance. With the identification of mutations in particular genes and the likely role of additional genes that are important in PD risk-susceptibility, appropriate protocols must be developed so that accurate and informative genetic counseling can be offered to families in which one or more members has PD. Further diagnostic testing should be delayed until more is learned about the frequency, penetrance, and risk assessment of certain gene mutations. Important lessons can be learned from the implementation of counseling protocols for other neurodegenerative disorders, such as Huntington disease and Alzheimer disease.

Original languageEnglish
Pages (from-to)235-242
Number of pages8
JournalNeuroRx
Volume1
Issue number2
DOIs
StatePublished - Apr 2004

Fingerprint

Inborn Genetic Diseases
Parkinson Disease
Genes
Mutation
Disease Susceptibility
Neurodegenerative Diseases
Inheritance Patterns
alpha-Synuclein
Penetrance
Huntington Disease
Genetic Counseling
Proteasome Endopeptidase Complex
Ubiquitin
Counseling
Alzheimer Disease

Keywords

  • genetic counseling
  • genetics
  • Parkinson disease
  • review
  • ubiquitin-proteasome system

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Genetics of Parkinson Disease. / Pankratz, Nathan; Foroud, Tatiana.

In: NeuroRx, Vol. 1, No. 2, 04.2004, p. 235-242.

Research output: Contribution to journalArticle

Pankratz, Nathan ; Foroud, Tatiana. / Genetics of Parkinson Disease. In: NeuroRx. 2004 ; Vol. 1, No. 2. pp. 235-242.
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