Genetics of psychiatric disorders

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

The major psychiatric disorders are common disorders with a complex genetics, similar to other common medical disorders such as diabetes and hypertension. For most of these disorders, linkage studies in families with multiple cases have revealed chromosomal areas that contain susceptibility genes. In recent years, specific single genes have begun to be identified for disorders such as schizophrenia (e.g., DISC1, neuregulin), bipolar affective disorder (G72, BDNF), autism (neuroligins), attention-deficit disorder (DAT, DRD4), AND alcohol dependence (GABRA2, ADH4). Genome-wide association studies in large case-control data sets are now in progress, which may confirm and extend such reports. Genetic studies of Alzheimer's disease (APOE) and several forms of mental retardation (Down's syndrome, Fragile X) are already well advanced. Functional studies related to single gene vulnerability factors are now beginning. Important clues are emerging from gene expression studies and epigenetics. It is anticipated that new diagnostic tools and therapeutic strategies will result from this work.

Original languageEnglish
Title of host publicationtThe Medical Basis of Psychiatry: Third Edition
PublisherHumana Press
Pages487-518
Number of pages32
ISBN (Print)9781588299178
DOIs
StatePublished - 2008

Fingerprint

Inborn Genetic Diseases
Psychiatry
Neuregulins
Genes
Genome-Wide Association Study
Brain-Derived Neurotrophic Factor
Attention Deficit Disorder with Hyperactivity
Autistic Disorder
Down Syndrome
Mood Disorders
Bipolar Disorder
Epigenomics
Intellectual Disability
Alcoholism
Schizophrenia
Alzheimer Disease
Hypertension
Gene Expression
Therapeutics

Keywords

  • Alcohol dependence
  • Bipolar affective disorder
  • Candidate genes
  • Endophenotypes
  • Epigenetics
  • Genetics
  • Molecular genetics
  • Schizophrenia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nurnberger, J., Berrettini, W., & Niculescu, A. (2008). Genetics of psychiatric disorders. In tThe Medical Basis of Psychiatry: Third Edition (pp. 487-518). Humana Press. https://doi.org/10.1007/978-1-59745-252-6_29

Genetics of psychiatric disorders. / Nurnberger, John; Berrettini, Wade; Niculescu, Alexander.

tThe Medical Basis of Psychiatry: Third Edition. Humana Press, 2008. p. 487-518.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nurnberger, J, Berrettini, W & Niculescu, A 2008, Genetics of psychiatric disorders. in tThe Medical Basis of Psychiatry: Third Edition. Humana Press, pp. 487-518. https://doi.org/10.1007/978-1-59745-252-6_29
Nurnberger J, Berrettini W, Niculescu A. Genetics of psychiatric disorders. In tThe Medical Basis of Psychiatry: Third Edition. Humana Press. 2008. p. 487-518 https://doi.org/10.1007/978-1-59745-252-6_29
Nurnberger, John ; Berrettini, Wade ; Niculescu, Alexander. / Genetics of psychiatric disorders. tThe Medical Basis of Psychiatry: Third Edition. Humana Press, 2008. pp. 487-518
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