Genetics of psychiatric disorders

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The major psychiatric disorders are common disorders with a complex genetics, similar to other common medical disorders such as diabetes and hypertension. For most of these disorders, linkage studies in families with multiple cases have revealed chromosomal areas that contain susceptibility genes. In recent years, genes have begun to be identified for disorders such as schizophrenia (e.g., DISC1, TCF4, ZNF804A), bipolar affective disorder (CACNA1C, ODZ4), autism (neuroligins, neurexins), attention deficit disorder (DAT, DRD4), and alcohol dependence (GABRA2, ADH4). Genetic studies of Alzheimer's Disease (APOE) and several forms of mental retardation (Down's Syndrome, Fragile X) are already well advanced. Functional studies related to single gene vulnerability factors are now beginning. Important clues are emerging from gene expression studies and epigenetics. It is anticipated that new diagnostic tools and therapeutic strategies will result from this work.

Original languageEnglish (US)
Title of host publicationThe Medical Basis of Psychiatry
Subtitle of host publicationFourth Edition
PublisherSpringer New York
Pages553-600
Number of pages48
ISBN (Electronic)9781493925285
ISBN (Print)9781493925278
DOIs
StatePublished - Jan 1 2016

Fingerprint

Inborn Genetic Diseases
Psychiatry
Genes
Attention Deficit Disorder with Hyperactivity
Autistic Disorder
Down Syndrome
Mood Disorders
Bipolar Disorder
Epigenomics
Intellectual Disability
Alcoholism
Schizophrenia
Alzheimer Disease
Hypertension
Gene Expression
Therapeutics

Keywords

  • Alcohol dependence
  • Bipolar affective disorder
  • Candidate genes
  • Genetics
  • Molecular genetics
  • Schizophrenia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nurnberger, J., Berrettini, W., & Niculescu, A. (2016). Genetics of psychiatric disorders. In The Medical Basis of Psychiatry: Fourth Edition (pp. 553-600). Springer New York. https://doi.org/10.1007/978-1-4939-2528-5_29

Genetics of psychiatric disorders. / Nurnberger, John; Berrettini, Wade; Niculescu, Alexander.

The Medical Basis of Psychiatry: Fourth Edition. Springer New York, 2016. p. 553-600.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nurnberger, J, Berrettini, W & Niculescu, A 2016, Genetics of psychiatric disorders. in The Medical Basis of Psychiatry: Fourth Edition. Springer New York, pp. 553-600. https://doi.org/10.1007/978-1-4939-2528-5_29
Nurnberger J, Berrettini W, Niculescu A. Genetics of psychiatric disorders. In The Medical Basis of Psychiatry: Fourth Edition. Springer New York. 2016. p. 553-600 https://doi.org/10.1007/978-1-4939-2528-5_29
Nurnberger, John ; Berrettini, Wade ; Niculescu, Alexander. / Genetics of psychiatric disorders. The Medical Basis of Psychiatry: Fourth Edition. Springer New York, 2016. pp. 553-600
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