Genetics of restless legs syndrome

Ignacio F. Mata, Cynthia Bodkin, Charles H. Adler, Siong Chi Lin, Ryan J. Uitti, Matthew J. Farrer, Zbigniew K. Wszolek

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Restless legs syndrome (RLS) is a common disorder, although under-diagnosed, with a prevalence of up to 15% depending on the population sampled. Familial aggregation has been widely shown since Ekbom formerly described the condition in 1960; twin studies support a genetic contribution in the development of this disorder. Molecular genetic approaches have identified three genomic regions in RLS susceptibility, however no specific mutations have yet been identified. Herein, we review the current status of genetics in RLS, providing some methodological guidelines to help future research.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalParkinsonism and Related Disorders
Volume12
Issue number1
DOIs
StatePublished - Jan 2006
Externally publishedYes

Fingerprint

Restless Legs Syndrome
Twin Studies
Molecular Biology
Guidelines
Mutation
Population

Keywords

  • Genetics
  • Restless legs syndrome
  • Review

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Neurology

Cite this

Mata, I. F., Bodkin, C., Adler, C. H., Lin, S. C., Uitti, R. J., Farrer, M. J., & Wszolek, Z. K. (2006). Genetics of restless legs syndrome. Parkinsonism and Related Disorders, 12(1), 1-7. https://doi.org/10.1016/j.parkreldis.2005.08.006

Genetics of restless legs syndrome. / Mata, Ignacio F.; Bodkin, Cynthia; Adler, Charles H.; Lin, Siong Chi; Uitti, Ryan J.; Farrer, Matthew J.; Wszolek, Zbigniew K.

In: Parkinsonism and Related Disorders, Vol. 12, No. 1, 01.2006, p. 1-7.

Research output: Contribution to journalArticle

Mata, IF, Bodkin, C, Adler, CH, Lin, SC, Uitti, RJ, Farrer, MJ & Wszolek, ZK 2006, 'Genetics of restless legs syndrome', Parkinsonism and Related Disorders, vol. 12, no. 1, pp. 1-7. https://doi.org/10.1016/j.parkreldis.2005.08.006
Mata, Ignacio F. ; Bodkin, Cynthia ; Adler, Charles H. ; Lin, Siong Chi ; Uitti, Ryan J. ; Farrer, Matthew J. ; Wszolek, Zbigniew K. / Genetics of restless legs syndrome. In: Parkinsonism and Related Disorders. 2006 ; Vol. 12, No. 1. pp. 1-7.
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