Genetics of restless legs syndrome

Ignacio F. Mata, Cynthia L. Bodkin, Charles H. Adler, Siong Chi Lin, Ryan J. Uitti, Matthew J. Farrer, Zbigniew K. Wszolek

Research output: Contribution to journalReview article

11 Scopus citations


Restless legs syndrome (RLS) is a common disorder, although under-diagnosed, with a prevalence of up to 15% depending on the population sampled. Familial aggregation has been widely shown since Ekbom formerly described the condition in 1960; twin studies support a genetic contribution in the development of this disorder. Molecular genetic approaches have identified three genomic regions in RLS susceptibility, however no specific mutations have yet been identified. Herein, we review the current status of genetics in RLS, providing some methodological guidelines to help future research.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalParkinsonism and Related Disorders
Issue number1
StatePublished - Jan 1 2006
Externally publishedYes


  • Genetics
  • Restless legs syndrome
  • Review

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

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  • Cite this

    Mata, I. F., Bodkin, C. L., Adler, C. H., Lin, S. C., Uitti, R. J., Farrer, M. J., & Wszolek, Z. K. (2006). Genetics of restless legs syndrome. Parkinsonism and Related Disorders, 12(1), 1-7.