Genitourinary anomalies in the charge association

David C. Ragan, Anthony J. Casale, Richard C. Rink, Mark P. Cain, David Weaver

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Purpose: We identified the incidence and types of genital and urinary anomalies, and established a plan for evaluating the urinary system in the CHARGE association. Materials and Methods: We retrospectively reviewed the charts of 32 patients in whom the CHARGE association was diagnosed. Results: Of the 32 patients identified 22 (69%) had genitourinary abnormalities. Genital anomalies, including micropenis, penile agenesis, hypospadias, chordee, cryptorchidism, a bifid scrotum, atresia of the uterus, cervix and vagina, and hypoplastic labia majora, labia minora and clitoris, were present in 18 patients (56%). Of the 24 patients who underwent renal ultrasound 10 (42%) were diagnosed with urinary tract anomalies including a solitary kidney, hydronephrosis, renal hypoplasia and duplex kidneys. Further evaluation revealed vesicoureteral reflux, neurogenic bladder secondary to spinal dysraphism, nephrolithiasis, ureteropelvic junction obstruction and a nonfunctioning upper pole in both duplex kidneys. Conclusions: There is a high incidence of genitourinary anomalies in the CHARGE association. Because of this high incidence of anomalies, patients with this condition should undergo a careful genitourinary evaluation, including renal and bladder ultrasound, and voiding cystourethrography screening.

Original languageEnglish
Pages (from-to)622-625
Number of pages4
JournalJournal of Urology
Volume161
Issue number2
StatePublished - Feb 1999

Fingerprint

CHARGE Syndrome
Kidney
Incidence
Urogenital Abnormalities
Clitoris
Nephrolithiasis
Neurogenic Urinary Bladder
Hypospadias
Vesico-Ureteral Reflux
Spinal Dysraphism
Scrotum
Cryptorchidism
Hydronephrosis
Vagina
Urinary Tract
Cervix Uteri
Urinary Bladder

Keywords

  • Abnormalities
  • Choanal atresia
  • Urogenital system

ASJC Scopus subject areas

  • Urology

Cite this

Ragan, D. C., Casale, A. J., Rink, R. C., Cain, M. P., & Weaver, D. (1999). Genitourinary anomalies in the charge association. Journal of Urology, 161(2), 622-625.

Genitourinary anomalies in the charge association. / Ragan, David C.; Casale, Anthony J.; Rink, Richard C.; Cain, Mark P.; Weaver, David.

In: Journal of Urology, Vol. 161, No. 2, 02.1999, p. 622-625.

Research output: Contribution to journalArticle

Ragan, DC, Casale, AJ, Rink, RC, Cain, MP & Weaver, D 1999, 'Genitourinary anomalies in the charge association', Journal of Urology, vol. 161, no. 2, pp. 622-625.
Ragan DC, Casale AJ, Rink RC, Cain MP, Weaver D. Genitourinary anomalies in the charge association. Journal of Urology. 1999 Feb;161(2):622-625.
Ragan, David C. ; Casale, Anthony J. ; Rink, Richard C. ; Cain, Mark P. ; Weaver, David. / Genitourinary anomalies in the charge association. In: Journal of Urology. 1999 ; Vol. 161, No. 2. pp. 622-625.
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