Genitourinary small cell malignancies: Prostate and bladder

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Small cell carcinoma is an aggressive malignancy often associated with dismal prognosis due to the presence of advanced disease. Small cell malignancies, initially described in the lung (small cell carcinoma of the lung), can occur in extrapulmonary sites, such as prostate (small cell carcinoma of the prostate) and bladder (small cell carcinoma of the bladder), with similar clinicopathologic outcomes. There has been a paradigm shift in the management of small cell carcinoma of the lung from initial surgical treatment to use of chemotherapy followed by local therapies. Such treatment modalities have been applied to small cell carcinoma of the prostate and the bladder, with promise in improving patient survival. Use of platinum-based combination chemotherapy followed by surgical resection and/or radiation offers the most benefit. Further investigation at the molecular level may offer targeted therapies earlier in the course of the disease.

Original languageEnglish (US)
Pages (from-to)479-488
Number of pages10
JournalFuture Oncology
Volume11
Issue number3
DOIs
StatePublished - Feb 1 2015

Keywords

  • bladder cancer
  • chemotherapy
  • prostate cancer
  • radiotherapy
  • small cell carcinoma
  • surgery

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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