Genome screen for platelet monoamine oxidase (MAO) activity

Nancy L. Saccone, John P. Rice, Nan Rochberg, Alison Goate, Theodore Reich, Shantia Shears, William Wu, John I. Nurnberger, Tatiana Foroud, Howard J. Edenberg, Ting Kai Li

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

To identify loci involved in the control of platelet monoamine oxidase B (MAO-B) activity, a genomewide linkage screen was performed using 291 markers in 148 nuclear families containing a total of 1,008 nonindependent sib-pairs. Participants were genotyped and their platelet MAO-B activity levels were measured as part of the Collaborative Study on the Genetics of Alcoholism (COGA). Sib-pair analysis using Haseman-Elston regression was carried out with two programs. Two-point analysis on all pairs with SIBPAL indicated three markers with p-values below 0.01:D6S1018 (p=0.0004), D2S1328 (p=0.008), and D2S408 (p=0.003). MAPMAKER/SIBS multipoint analyses using independent pairs(N=409) gave maximal lod scores of 2.0 on chromosome 6 and 1.1 and 1.4 for the two regions on chromosome 2. These results are consistent with linkage, but do not provide definitive evidence. We are currently creating a denser map in these regions and have begun genotyping a second sample in COGA.

Original languageEnglish (US)
Pages (from-to)517-521
Number of pages5
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume88
Issue number5
DOIs
StatePublished - Oct 15 1999

Keywords

  • Linkage
  • MAO activity
  • Quantitative trait
  • Sib-pair analysis

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

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