Genome-wide association studies identify loci associated with age at menarche and age at natural menopause

Chunyan He, Peter Kraft, Constance Chen, Julie E. Buring, Guillaume Paré, Susan E. Hankinson, Stephen J. Chanock, Paul M. Ridker, David J. Hunter, Daniel I. Chasman

Research output: Contribution to journalArticle

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Abstract

Age at menarche and age at natural menopause are associated with causes of substantial morbidity and mortality such as breast cancer and cardiovascular disease. We conducted a joint analysis of two genome-wide association studies of these two traits in a total of 17,438 women from the Nurses' Health Study (NHS, N = 2,287) and the Women's Genome Health Study (WGHS, N = 15,151). For age at menarche, we identified ten associated SNPs (P = 1 × 10 7 -3 × 10 13) clustered at 6q21 (in or near the gene LIN28B) and 9q31.2 (in an intergenic region). For age at natural menopause, we identified 13 associated SNPs (P = 1 × 10 7 -1 × 10 21) clustered at 20p12.3 (in the gene MCM8), 19q13.42 (in or near the gene BRSK1), 5q35.2 (in or near genes UIMC1 and HK3) and 6p24.2 (in the gene SYCP2L). These newly identified loci might expand understanding of the biological pathways regulating these two traits.

Original languageEnglish (US)
Pages (from-to)724-728
Number of pages5
JournalNature Genetics
Volume41
Issue number6
DOIs
StatePublished - Jun 2009
Externally publishedYes

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Menarche
Genome-Wide Association Study
Menopause
Genes
Women's Health
Single Nucleotide Polymorphism
Breast Diseases
Intergenic DNA
Cardiovascular Diseases
Nurses
Genome
Breast Neoplasms
Morbidity
Mortality

ASJC Scopus subject areas

  • Genetics
  • Medicine(all)

Cite this

He, C., Kraft, P., Chen, C., Buring, J. E., Paré, G., Hankinson, S. E., ... Chasman, D. I. (2009). Genome-wide association studies identify loci associated with age at menarche and age at natural menopause. Nature Genetics, 41(6), 724-728. https://doi.org/10.1038/ng.385

Genome-wide association studies identify loci associated with age at menarche and age at natural menopause. / He, Chunyan; Kraft, Peter; Chen, Constance; Buring, Julie E.; Paré, Guillaume; Hankinson, Susan E.; Chanock, Stephen J.; Ridker, Paul M.; Hunter, David J.; Chasman, Daniel I.

In: Nature Genetics, Vol. 41, No. 6, 06.2009, p. 724-728.

Research output: Contribution to journalArticle

He, C, Kraft, P, Chen, C, Buring, JE, Paré, G, Hankinson, SE, Chanock, SJ, Ridker, PM, Hunter, DJ & Chasman, DI 2009, 'Genome-wide association studies identify loci associated with age at menarche and age at natural menopause', Nature Genetics, vol. 41, no. 6, pp. 724-728. https://doi.org/10.1038/ng.385
He, Chunyan ; Kraft, Peter ; Chen, Constance ; Buring, Julie E. ; Paré, Guillaume ; Hankinson, Susan E. ; Chanock, Stephen J. ; Ridker, Paul M. ; Hunter, David J. ; Chasman, Daniel I. / Genome-wide association studies identify loci associated with age at menarche and age at natural menopause. In: Nature Genetics. 2009 ; Vol. 41, No. 6. pp. 724-728.
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