Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma

Harvind S. Chahal, Wenting Wu, Katherine J. Ransohoff, Lingyao Yang, Haley Hedlin, Manisha Desai, Yuan Lin, Hong Ji Dai, Abrar A. Qureshi, Wen Qing Li, Peter Kraft, David A. Hinds, Jean Y. Tang, Jiali Han, Kavita Y. Sarin

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Basal cell carcinoma (BCC) is the most common cancer worldwide with an annual incidence of 2.8 million cases in the United States alone. Previous studies have demonstrated an association between 21 distinct genetic loci and BCC risk. Here, we report the results of a two-stage genome-wide association study of BCC, totalling 17,187 cases and 287,054 controls. We confirm 17 previously reported loci and identify 14 new susceptibility loci reaching genome-wide significance (P<5 × 10-8, logistic regression). These newly associated SNPs lie within predicted keratinocyte regulatory elements and in expression quantitative trait loci; furthermore, we identify candidate genes and non-coding RNAs involved in telomere maintenance, immune regulation and tumour progression, providing deeper insight into the pathogenesis of BCC.

Original languageEnglish (US)
Article number12510
JournalNature Communications
Volume7
DOIs
StatePublished - Aug 19 2016

Fingerprint

genome
Genome-Wide Association Study
Basal Cell Carcinoma
loci
Genes
cancer
Alleles
Cells
Untranslated RNA
telomeres
Genetic Loci
Logistics
Tumors
Quantitative Trait Loci
Telomere
pathogenesis
Keratinocytes
Single Nucleotide Polymorphism
logistics
Neoplasms

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Chahal, H. S., Wu, W., Ransohoff, K. J., Yang, L., Hedlin, H., Desai, M., ... Sarin, K. Y. (2016). Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma. Nature Communications, 7, [12510]. https://doi.org/10.1038/ncomms12510

Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma. / Chahal, Harvind S.; Wu, Wenting; Ransohoff, Katherine J.; Yang, Lingyao; Hedlin, Haley; Desai, Manisha; Lin, Yuan; Dai, Hong Ji; Qureshi, Abrar A.; Li, Wen Qing; Kraft, Peter; Hinds, David A.; Tang, Jean Y.; Han, Jiali; Sarin, Kavita Y.

In: Nature Communications, Vol. 7, 12510, 19.08.2016.

Research output: Contribution to journalArticle

Chahal, HS, Wu, W, Ransohoff, KJ, Yang, L, Hedlin, H, Desai, M, Lin, Y, Dai, HJ, Qureshi, AA, Li, WQ, Kraft, P, Hinds, DA, Tang, JY, Han, J & Sarin, KY 2016, 'Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma', Nature Communications, vol. 7, 12510. https://doi.org/10.1038/ncomms12510
Chahal, Harvind S. ; Wu, Wenting ; Ransohoff, Katherine J. ; Yang, Lingyao ; Hedlin, Haley ; Desai, Manisha ; Lin, Yuan ; Dai, Hong Ji ; Qureshi, Abrar A. ; Li, Wen Qing ; Kraft, Peter ; Hinds, David A. ; Tang, Jean Y. ; Han, Jiali ; Sarin, Kavita Y. / Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma. In: Nature Communications. 2016 ; Vol. 7.
@article{518b61366a874a5d864abd3f323b7cca,
title = "Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma",
abstract = "Basal cell carcinoma (BCC) is the most common cancer worldwide with an annual incidence of 2.8 million cases in the United States alone. Previous studies have demonstrated an association between 21 distinct genetic loci and BCC risk. Here, we report the results of a two-stage genome-wide association study of BCC, totalling 17,187 cases and 287,054 controls. We confirm 17 previously reported loci and identify 14 new susceptibility loci reaching genome-wide significance (P<5 × 10-8, logistic regression). These newly associated SNPs lie within predicted keratinocyte regulatory elements and in expression quantitative trait loci; furthermore, we identify candidate genes and non-coding RNAs involved in telomere maintenance, immune regulation and tumour progression, providing deeper insight into the pathogenesis of BCC.",
author = "Chahal, {Harvind S.} and Wenting Wu and Ransohoff, {Katherine J.} and Lingyao Yang and Haley Hedlin and Manisha Desai and Yuan Lin and Dai, {Hong Ji} and Qureshi, {Abrar A.} and Li, {Wen Qing} and Peter Kraft and Hinds, {David A.} and Tang, {Jean Y.} and Jiali Han and Sarin, {Kavita Y.}",
year = "2016",
month = "8",
day = "19",
doi = "10.1038/ncomms12510",
language = "English (US)",
volume = "7",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma

AU - Chahal, Harvind S.

AU - Wu, Wenting

AU - Ransohoff, Katherine J.

AU - Yang, Lingyao

AU - Hedlin, Haley

AU - Desai, Manisha

AU - Lin, Yuan

AU - Dai, Hong Ji

AU - Qureshi, Abrar A.

AU - Li, Wen Qing

AU - Kraft, Peter

AU - Hinds, David A.

AU - Tang, Jean Y.

AU - Han, Jiali

AU - Sarin, Kavita Y.

PY - 2016/8/19

Y1 - 2016/8/19

N2 - Basal cell carcinoma (BCC) is the most common cancer worldwide with an annual incidence of 2.8 million cases in the United States alone. Previous studies have demonstrated an association between 21 distinct genetic loci and BCC risk. Here, we report the results of a two-stage genome-wide association study of BCC, totalling 17,187 cases and 287,054 controls. We confirm 17 previously reported loci and identify 14 new susceptibility loci reaching genome-wide significance (P<5 × 10-8, logistic regression). These newly associated SNPs lie within predicted keratinocyte regulatory elements and in expression quantitative trait loci; furthermore, we identify candidate genes and non-coding RNAs involved in telomere maintenance, immune regulation and tumour progression, providing deeper insight into the pathogenesis of BCC.

AB - Basal cell carcinoma (BCC) is the most common cancer worldwide with an annual incidence of 2.8 million cases in the United States alone. Previous studies have demonstrated an association between 21 distinct genetic loci and BCC risk. Here, we report the results of a two-stage genome-wide association study of BCC, totalling 17,187 cases and 287,054 controls. We confirm 17 previously reported loci and identify 14 new susceptibility loci reaching genome-wide significance (P<5 × 10-8, logistic regression). These newly associated SNPs lie within predicted keratinocyte regulatory elements and in expression quantitative trait loci; furthermore, we identify candidate genes and non-coding RNAs involved in telomere maintenance, immune regulation and tumour progression, providing deeper insight into the pathogenesis of BCC.

UR - http://www.scopus.com/inward/record.url?scp=84983372933&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84983372933&partnerID=8YFLogxK

U2 - 10.1038/ncomms12510

DO - 10.1038/ncomms12510

M3 - Article

C2 - 27539887

AN - SCOPUS:84983372933

VL - 7

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 12510

ER -