Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure

Alessia Visconti, David L. Duffy, Fan Liu, Gu Zhu, Wenting Wu, Yan Chen, Pirro G. Hysi, Changqing Zeng, Marianna Sanna, Mark M. Iles, Peter A. Kanetsky, Florence Demenais, Merel A. Hamer, Andre G. Uitterlinden, M. Arfan Ikram, Tamar Nijsten, Nicholas G. Martin, Manfred Kayser, Tim D. Spector, Jiali HanVeronique Bataille, Mario Falchi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The skin's tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report a large genome-wide association study of ease of skin tanning in 176,678 subjects of European ancestry. We identify significant association with tanning ability at 20 loci. We confirm previously identified associations at six of these loci, and report 14 novel loci, of which ten have never been associated with pigmentation-related phenotypes. Our results also suggest that variants at the AHR/AGR3 locus, previously associated with cutaneous malignant melanoma the underlying mechanism of which is poorly understood, might act on disease risk through modulation of tanning ability.

Original languageEnglish (US)
Article number1684
JournalNature Communications
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2018

Fingerprint

Tanning
Genetic Loci
genome
Genome-Wide Association Study
Solar System
loci
Sun
Skin
sun
Genes
Sunburn
Pigmentation
Skin Neoplasms
phenotype
Modulation
Phenotype
tendencies
cancer
modulation

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure. / Visconti, Alessia; Duffy, David L.; Liu, Fan; Zhu, Gu; Wu, Wenting; Chen, Yan; Hysi, Pirro G.; Zeng, Changqing; Sanna, Marianna; Iles, Mark M.; Kanetsky, Peter A.; Demenais, Florence; Hamer, Merel A.; Uitterlinden, Andre G.; Ikram, M. Arfan; Nijsten, Tamar; Martin, Nicholas G.; Kayser, Manfred; Spector, Tim D.; Han, Jiali; Bataille, Veronique; Falchi, Mario.

In: Nature Communications, Vol. 9, No. 1, 1684, 01.12.2018.

Research output: Contribution to journalArticle

Visconti, A, Duffy, DL, Liu, F, Zhu, G, Wu, W, Chen, Y, Hysi, PG, Zeng, C, Sanna, M, Iles, MM, Kanetsky, PA, Demenais, F, Hamer, MA, Uitterlinden, AG, Ikram, MA, Nijsten, T, Martin, NG, Kayser, M, Spector, TD, Han, J, Bataille, V & Falchi, M 2018, 'Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure', Nature Communications, vol. 9, no. 1, 1684. https://doi.org/10.1038/s41467-018-04086-y
Visconti, Alessia ; Duffy, David L. ; Liu, Fan ; Zhu, Gu ; Wu, Wenting ; Chen, Yan ; Hysi, Pirro G. ; Zeng, Changqing ; Sanna, Marianna ; Iles, Mark M. ; Kanetsky, Peter A. ; Demenais, Florence ; Hamer, Merel A. ; Uitterlinden, Andre G. ; Ikram, M. Arfan ; Nijsten, Tamar ; Martin, Nicholas G. ; Kayser, Manfred ; Spector, Tim D. ; Han, Jiali ; Bataille, Veronique ; Falchi, Mario. / Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure. In: Nature Communications. 2018 ; Vol. 9, No. 1.
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