Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid

for the Alzheimer's Disease Neuroimaging Initiative

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Prolactin is a polypeptide hormone secreted by the anterior pituitary gland that plays an essential role in lactation, tissue growth, and suppressing apoptosis to increase cell survival. Prolactin serves as a key player in many life-critical processes, including immune system and reproduction. Prolactin is also found in multiple fluids throughout the body, including plasma and cerebrospinal fluid (CSF). Methods: In this study, we measured prolactin levels in both plasma and CSF, and performed a genome-wide association study. We then performed meta-analyses using METAL with a significance threshold of p < 5 × 10-8 and removed SNPs where the direction of the effect was different between the two datasets. Results: We identified 12 SNPs associated with increased prolactin levels in both biological fluids. Conclusions: Our efforts will help researchers understand how prolactin is regulated in both CSF and plasma, which could be beneficial in research for the immune system and reproduction.

Original languageEnglish (US)
Article number436
JournalBMC Genomics
Volume17
DOIs
StatePublished - Jun 29 2016

Fingerprint

Genome-Wide Association Study
Prolactin
Cerebrospinal Fluid
Immune System Phenomena
Single Nucleotide Polymorphism
Reproduction
Anterior Pituitary Gland
Peptide Hormones
Body Fluids
Lactation
Meta-Analysis
Immune System
Cell Survival
Research Personnel
Apoptosis
Growth
Research

Keywords

  • Association
  • CSF
  • Genetics
  • Plasma
  • Prolactin

ASJC Scopus subject areas

  • Biotechnology
  • Genetics

Cite this

Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid. / for the Alzheimer's Disease Neuroimaging Initiative.

In: BMC Genomics, Vol. 17, 436, 29.06.2016.

Research output: Contribution to journalArticle

for the Alzheimer's Disease Neuroimaging Initiative. / Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid. In: BMC Genomics. 2016 ; Vol. 17.
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AU - Saykin, Andrew

AU - Morris, John

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