Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty

The ReproGen Consortium, The Early Growth Genetics (EGG) Consortium, The Early Growth Genetics (EGG) Consortium, The ReproGen Consortium, The GIANT Consortium

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Little is known about genes regulating male puberty. Further, while many identified pubertal timing 1variants associate with age at menarche, a late manifestation of puberty, and body mass, little is known about these variants' relationship to pubertal initiation or tempo. To address these questions, we performed genome-wide association meta-analysis in over 11 000 European samples with data on early pubertal traits, male genital and female breast development, measured by the Tanner scale. We report the first genome-wide significant locus for male sexual development upstream of myocardin-like 2 (MKL2) (P = 8.9×10- 9 ), amenarche locus tagging a developmental pathway linking earlier puberty with reduced pubertal growth (P = 4.6×10 -5 ) and short adult stature (p = 7.5×10 -6 ) in both males and females. Furthermore, our results indicate that a proportion of menarche loci are important for pubertal initiation in both sexes. Consistent with epidemiological correlations between increased prepubertal body mass and earlier pubertal timing in girls, body mass index (BMI)-increasing alleles correlated with earlier breast development. In boys, some BMI-increasing alleles associated with earlier, and others with delayed, sexual development; these genetic results mimic the controversy in epidemiological studies, some of which show opposing correlations between prepubertal BMI and male puberty. Our results contribute to our understanding of the pubertal initiation program in both sexes and indicate that although mechanisms regulating pubertal onset in males and females may largely be shared, the relationship between body mass and pubertal timing in boys may be complex and requires further genetic studies.

Original languageEnglish (US)
Pages (from-to)4452-4464
Number of pages13
JournalHuman molecular genetics
Volume23
Issue number16
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Sexual Maturation
Menarche
Genome-Wide Association Study
Puberty
Sexual Development
Body Mass Index
Breast
Alleles
Meta-Analysis
Epidemiologic Studies
Genome
Growth
Genes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

The ReproGen Consortium, The Early Growth Genetics (EGG) Consortium, The Early Growth Genetics (EGG) Consortium, The ReproGen Consortium, & The GIANT Consortium (2014). Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty. Human molecular genetics, 23(16), 4452-4464. https://doi.org/10.1093/hmg/ddu150

Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty. / The ReproGen Consortium; The Early Growth Genetics (EGG) Consortium; The Early Growth Genetics (EGG) Consortium; The ReproGen Consortium; The GIANT Consortium.

In: Human molecular genetics, Vol. 23, No. 16, 01.01.2014, p. 4452-4464.

Research output: Contribution to journalArticle

The ReproGen Consortium, The Early Growth Genetics (EGG) Consortium, The Early Growth Genetics (EGG) Consortium, The ReproGen Consortium & The GIANT Consortium 2014, 'Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty', Human molecular genetics, vol. 23, no. 16, pp. 4452-4464. https://doi.org/10.1093/hmg/ddu150
The ReproGen Consortium, The Early Growth Genetics (EGG) Consortium, The Early Growth Genetics (EGG) Consortium, The ReproGen Consortium, The GIANT Consortium. Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty. Human molecular genetics. 2014 Jan 1;23(16):4452-4464. https://doi.org/10.1093/hmg/ddu150
The ReproGen Consortium ; The Early Growth Genetics (EGG) Consortium ; The Early Growth Genetics (EGG) Consortium ; The ReproGen Consortium ; The GIANT Consortium. / Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty. In: Human molecular genetics. 2014 ; Vol. 23, No. 16. pp. 4452-4464.
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abstract = "Little is known about genes regulating male puberty. Further, while many identified pubertal timing 1variants associate with age at menarche, a late manifestation of puberty, and body mass, little is known about these variants' relationship to pubertal initiation or tempo. To address these questions, we performed genome-wide association meta-analysis in over 11 000 European samples with data on early pubertal traits, male genital and female breast development, measured by the Tanner scale. We report the first genome-wide significant locus for male sexual development upstream of myocardin-like 2 (MKL2) (P = 8.9×10- 9 ), amenarche locus tagging a developmental pathway linking earlier puberty with reduced pubertal growth (P = 4.6×10 -5 ) and short adult stature (p = 7.5×10 -6 ) in both males and females. Furthermore, our results indicate that a proportion of menarche loci are important for pubertal initiation in both sexes. Consistent with epidemiological correlations between increased prepubertal body mass and earlier pubertal timing in girls, body mass index (BMI)-increasing alleles correlated with earlier breast development. In boys, some BMI-increasing alleles associated with earlier, and others with delayed, sexual development; these genetic results mimic the controversy in epidemiological studies, some of which show opposing correlations between prepubertal BMI and male puberty. Our results contribute to our understanding of the pubertal initiation program in both sexes and indicate that although mechanisms regulating pubertal onset in males and females may largely be shared, the relationship between body mass and pubertal timing in boys may be complex and requires further genetic studies.",
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AU - The Early Growth Genetics (EGG) Consortium

AU - The ReproGen Consortium

AU - The GIANT Consortium

AU - Cousminer, Diana L.

AU - Stergiakouli, Evangelia

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AU - Niinikoski, Harri

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AU - Panoutsopoulou, Kalliope

AU - Bustamante, Mariona

AU - Penninx, Brenda W.J.H.

AU - Murabito, Joanne

AU - Torrent, Maties

AU - Dedoussis, George V.

AU - Kiess, Wieland

AU - Boomsma, Dorret I.

AU - Pennell, Craig E.

AU - Raitakari, Olli T.

AU - Hyppönen, Elina

AU - Smith, George Davey

AU - Ripatti, Samuli

AU - McCarthy, Mark I.

AU - Widén, Elisabeth

AU - Adair, Linda S.

AU - Atalay, Mustafa

AU - van Beijsterveldt, Toos

AU - Bergen, Nienke

AU - Foroud, Tatiana

AU - Peacock, Munro

AU - Econs, Michael

PY - 2014/1/1

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