Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma

AMFS Investigators, ATHENS Melanoma Study Group, GenoMEL Consortium, Essen-Heidelberg Investigators, The SDH Study Group, Q-MEGA and QTWIN Investigators

Research output: Contribution to journalArticle

114 Scopus citations

Abstract

Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of CMM genome-wide association studies (GWAS). This meta-analysis combines 11 GWAS (5 previously unpublished) and a further three stage 2 data sets, totaling 15,990 CMM cases and 26,409 controls. Five loci not previously associated with CMM risk reached genome-wide significance (P < 5 × 10-8), as did 2 previously reported but unreplicated loci and all 13 established loci. Newly associated SNPs fall within putative melanocyte regulatory elements, and bioinformatic and expression quantitative trait locus (eQTL) data highlight candidate genes in the associated regions, including one involved in telomere biology.

Original languageEnglish (US)
Pages (from-to)987-995
Number of pages9
JournalNature genetics
Volume47
Issue number9
DOIs
StatePublished - Aug 27 2015

ASJC Scopus subject areas

  • Genetics

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    AMFS Investigators, ATHENS Melanoma Study Group, GenoMEL Consortium, Essen-Heidelberg Investigators, The SDH Study Group, & Q-MEGA and QTWIN Investigators (2015). Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. Nature genetics, 47(9), 987-995. https://doi.org/10.1038/ng.3373