Genomes and phenomes of a population of outbred rats and its progenitors

The Rat Genome Sequencing and Mapping Consortium

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Finding genetic variants that contribute to phenotypic variation is one of the main challenges of modern genetics. We used an outbred population of rats (Heterogeneous Stock, HS) in a combined sequence-based and genetic mapping analysis to identify sequence variants and genes contributing to complex traits of biomedical relevance. Here we describe the sequences of the eight inbred progenitors of the HS and the variants that segregate between them. We report the genotyping of 1,407 HS rats, and the collection from 2,006 rats of 195 phenotypic measures that are relevant to models of anxiety, type 2 diabetes, hypertension and osteoporosis. We make available haplotype dosages for the 1,407 genotyped rats, since genetic mapping in the HS is best carried out by reconstructing each HS chromosome as a mosaic of the progenitor genomes. Finally, we have deposited an R object that makes it easy to incorporate our sequence data into any genetic study of HS rats. Our genetic data are available for both Rnor3.4 and Rnor5.0 rat assemblies.

Original languageEnglish (US)
Article number140011
JournalScientific data
Volume1
DOIs
StatePublished - Jun 10 2014

Fingerprint

Rats
Genome
Genes
Osteoporosis
bone disease
Anxiety
Hypertension
Haplotype
Diabetes
hypertension
Chromosomes
Medical problems
Chromosome
chronic illness
Rat
anxiety
Gene

ASJC Scopus subject areas

  • Education
  • Library and Information Sciences
  • Computer Science Applications
  • Information Systems
  • Statistics, Probability and Uncertainty
  • Statistics and Probability

Cite this

Genomes and phenomes of a population of outbred rats and its progenitors. / The Rat Genome Sequencing and Mapping Consortium.

In: Scientific data, Vol. 1, 140011, 10.06.2014.

Research output: Contribution to journalArticle

The Rat Genome Sequencing and Mapping Consortium. / Genomes and phenomes of a population of outbred rats and its progenitors. In: Scientific data. 2014 ; Vol. 1.
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abstract = "Finding genetic variants that contribute to phenotypic variation is one of the main challenges of modern genetics. We used an outbred population of rats (Heterogeneous Stock, HS) in a combined sequence-based and genetic mapping analysis to identify sequence variants and genes contributing to complex traits of biomedical relevance. Here we describe the sequences of the eight inbred progenitors of the HS and the variants that segregate between them. We report the genotyping of 1,407 HS rats, and the collection from 2,006 rats of 195 phenotypic measures that are relevant to models of anxiety, type 2 diabetes, hypertension and osteoporosis. We make available haplotype dosages for the 1,407 genotyped rats, since genetic mapping in the HS is best carried out by reconstructing each HS chromosome as a mosaic of the progenitor genomes. Finally, we have deposited an R object that makes it easy to incorporate our sequence data into any genetic study of HS rats. Our genetic data are available for both Rnor3.4 and Rnor5.0 rat assemblies.",
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