Genomewide search for genes influencing percent body fat in Pima Indians: Suggestive linkage at chromosome 11q21-q22

R. A. Norman, D. B. Thompson, T. Foroud, W. T. Garvey, P. H. Bennett, C. Bogardus, E. Ravussin, Claire Allan, Leslie Baier, Donald Bowden, Robert Hanson, William Knowler, Sayuko Kobes, David Pettitt, Michal Prochazka

Research output: Contribution to journalArticle

130 Scopus citations

Abstract

On the basis of accumulating evidence that obesity has a substantial genetic component, a genomewide search for linkages of DNA markers to percent body fat is ongoing in Pima Indians, a population with a very high prevalence of obesity. An initial screen of the genome (>600 markers in 874 individuals) has been completed using highly polymorphic markers (mean heterozygosity = .67). Reported here are the sib-pair linkage results for percent body fat (277 siblings), the best available indicator of overall obesity. Single- marker linkages to percent body fat were evaluated by sib-pair analysis for quantitative traits. From these analyses, the best evidence of genes influencing body fat came from markers at chromosome 11q21-q22 and 3p24.2- p22 (P = .001; LOD = 2.0). Regions flanking these markers were further investigated by multipoint linkage. The evidence for linkage at 11q21-q22 increased to P = .0002 (LOD = 2.8), peaking between markers D11S2000 and D11S2366. Evidence for linkage at 3p24.2-p22 did not change. No association was detected for any marker in the region. Although several genes are known in the 11q21-q22 region, none have been implicated as candidate genes for obesity.

Original languageEnglish (US)
Pages (from-to)166-173
Number of pages8
JournalAmerican Journal of Human Genetics
Volume60
Issue number1
StatePublished - Jan 1997

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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    Norman, R. A., Thompson, D. B., Foroud, T., Garvey, W. T., Bennett, P. H., Bogardus, C., Ravussin, E., Allan, C., Baier, L., Bowden, D., Hanson, R., Knowler, W., Kobes, S., Pettitt, D., & Prochazka, M. (1997). Genomewide search for genes influencing percent body fat in Pima Indians: Suggestive linkage at chromosome 11q21-q22. American Journal of Human Genetics, 60(1), 166-173.