Genomic approaches to research in pulmonary hypertension

Mark W. Geraci, Bifeng Gao, Yasushi Hoshikawa, Michael E. Yeager, Rubin M. Tuder, Norbert F. Voelkel

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

Genomics, or the study of genes and their function, is a burgeoning field with many new technologies. In the present review, we explore the application of genomic approaches to the study of pulmonary hypertension (PH). Candidate genes, important to the pathobiology of the disease, have been investigated. Rodent models enable the manipulation of selected genes, either by transgenesis or targeted disruption. Mutational analysis of genes in the transforming growth factor-β family have proven pivotal in both familial and sporadic forms of primary PH. Finally, microarray gene expression analysis is a robust molecular tool to aid in delineating the pathobiology of this disease.

Original languageEnglish (US)
Pages (from-to)210-215
Number of pages6
JournalRespiratory Research
Volume2
Issue number4
DOIs
StatePublished - Dec 1 2001

Keywords

  • Genetic mutation
  • Knockout mouse
  • Microarray
  • Pulmonary hypertension
  • Transgenic mouse

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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    Geraci, M. W., Gao, B., Hoshikawa, Y., Yeager, M. E., Tuder, R. M., & Voelkel, N. F. (2001). Genomic approaches to research in pulmonary hypertension. Respiratory Research, 2(4), 210-215. https://doi.org/10.1186/rr59