Genomics of Brain Aging: Apolipoprotein E

Debomoy Lahiri, B. Maloney

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Apolipoprotein E (ApoE) is a cholesterol transport protein strongly implicated in risk for age-related neurodegenerative disorders, especially Alzheimer's disease (AD). The best characterized ApoE-associated risk for AD is due to one of three.APOE gene isoforms (.ε2/.ε3/.ε4), specifically the ε4 allele. This allele is not only associated with overall risk for AD but also with its appearance at an earlier age. In addition, it is associated with alterations in cerebral glucose metabolism and hippocampal loss due to age in individuals not diagnosed with AD or other dementia. Two APOE gene promoter polymorphisms also are likely to have a strong association with AD, and APOE likely participates in feedback to regulate its own expression.

Original languageEnglish
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages685-693
Number of pages9
ISBN (Print)9780080450469
DOIs
StatePublished - 2010

Fingerprint

Apolipoproteins E
Genomics
Alzheimer Disease
Brain
Alleles
Neurodegenerative Diseases
Genes
Dementia
Carrier Proteins
Protein Isoforms
Cholesterol
Glucose

Keywords

  • ?-Peptide
  • Aging
  • Amyloid
  • Brain
  • Cholesterol
  • Dementia
  • Epidemiology
  • Gene expression
  • Neurodegeneration risk factor
  • Promoter
  • Secretase
  • Transcription

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lahiri, D., & Maloney, B. (2010). Genomics of Brain Aging: Apolipoprotein E. In Encyclopedia of Neuroscience (pp. 685-693). Elsevier Ltd. https://doi.org/10.1016/B978-008045046-9.00136-4

Genomics of Brain Aging : Apolipoprotein E. / Lahiri, Debomoy; Maloney, B.

Encyclopedia of Neuroscience. Elsevier Ltd, 2010. p. 685-693.

Research output: Chapter in Book/Report/Conference proceedingChapter

Lahiri, D & Maloney, B 2010, Genomics of Brain Aging: Apolipoprotein E. in Encyclopedia of Neuroscience. Elsevier Ltd, pp. 685-693. https://doi.org/10.1016/B978-008045046-9.00136-4
Lahiri D, Maloney B. Genomics of Brain Aging: Apolipoprotein E. In Encyclopedia of Neuroscience. Elsevier Ltd. 2010. p. 685-693 https://doi.org/10.1016/B978-008045046-9.00136-4
Lahiri, Debomoy ; Maloney, B. / Genomics of Brain Aging : Apolipoprotein E. Encyclopedia of Neuroscience. Elsevier Ltd, 2010. pp. 685-693
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