Genomics of Brain Aging: Apolipoprotein E

D. K. Lahiri, B. Maloney

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Apolipoprotein E (ApoE) is a cholesterol transport protein strongly implicated in risk for age-related neurodegenerative disorders, especially Alzheimer's disease (AD). The best characterized ApoE-associated risk for AD is due to one of three.APOE gene isoforms (.ε2/.ε3/.ε4), specifically the ε4 allele. This allele is not only associated with overall risk for AD but also with its appearance at an earlier age. In addition, it is associated with alterations in cerebral glucose metabolism and hippocampal loss due to age in individuals not diagnosed with AD or other dementia. Two APOE gene promoter polymorphisms also are likely to have a strong association with AD, and APOE likely participates in feedback to regulate its own expression.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd.
Pages685-693
Number of pages9
ISBN (Print)9780080450469
DOIs
StatePublished - Jan 1 2009

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Keywords

  • ?-Peptide
  • Aging
  • Amyloid
  • Brain
  • Cholesterol
  • Dementia
  • Epidemiology
  • Gene expression
  • Neurodegeneration risk factor
  • Promoter
  • Secretase
  • Transcription

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lahiri, D. K., & Maloney, B. (2009). Genomics of Brain Aging: Apolipoprotein E. In Encyclopedia of Neuroscience (pp. 685-693). Elsevier Ltd.. https://doi.org/10.1016/B978-008045046-9.00136-4