Apolipoprotein E (ApoE) is a cholesterol transport protein strongly implicated in risk for age-related neurodegenerative disorders, especially Alzheimer's disease (AD). The best characterized ApoE-associated risk for AD is due to one of three.APOE gene isoforms (.ε2/.ε3/.ε4), specifically the ε4 allele. This allele is not only associated with overall risk for AD but also with its appearance at an earlier age. In addition, it is associated with alterations in cerebral glucose metabolism and hippocampal loss due to age in individuals not diagnosed with AD or other dementia. Two APOE gene promoter polymorphisms also are likely to have a strong association with AD, and APOE likely participates in feedback to regulate its own expression.
- Gene expression
- Neurodegeneration risk factor
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