Genomics of Pulmonary Arterial Hypertension: Implications for Therapy

Mark W. Geraci, Todd M. Bull, Rubin M. Tuder

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Pulmonary arterial hypertension (PAH) remains a vexing clinical disease with no cure. Despite advances and the discovery of a gene (BMPR2) associated with many of the hereditary forms of the disease, and some cases not previously known to be inherited, the reasons for mutations in this gene as a cause remain somewhat elusive. Clearly, a complex interplay exists between genetic alterations, environmental exposures (including infections), and disease development. This article addresses the advances in the genetics of PAH, including the identification of genetic etiologies and modulators, and the role of genetics in predicting disease progression and targeting therapeutics.

Original languageEnglish (US)
Pages (from-to)101-114
Number of pages14
JournalHeart Failure Clinics
Volume6
Issue number1
DOIs
StatePublished - Jan 1 2010

Keywords

  • Gene expression
  • Genetics
  • Genomics
  • Microarray
  • Pulmonary hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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