Genotype-specific concordance of chlamydia trachomatis genital infection within heterosexual partnerships

Julia A. Schillinger, Barry Katz, Lauri E. Markowitz, Phillip G. Braslins, Lydia A. Shrier, Guillermo Madico, Barbara Van Der Pol, Donald P. Orr, Peter A. Rice, Byron Batteiger

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Sexual transmission rates of Chlamydia trachomatis (Ct) cannot be measured directly; however, the study of concordance of Ct infection in sexual partnerships (dyads) can help to illuminate factors influencing Ct transmission. Methods: Heterosexual men and women with Ct infection and their sex partners were enrolled and partner-specific coital and behavioral data collected for the prior 30 days. Microbiological data included Ct culture, and nucleic acid amplification testing (NAAT), quantitative Ct polymerase chain reaction, and ompA genotyping. We measured Ct concordance in dyads and factors (correlates) associated with concordance. Results: One hundred twenty-one women and 125 men formed 128 dyads. Overall, 72.9%ofmale partners ofNAAT-positivewomen and 68.6%of female partners of NAAT-positive men were Ct-infected. Concordance was more common in dyads with culture-positive members (78.6% of male partners, 77% of female partners). Partners of women and men who were NAAT-positive only had lower concordance (33.3%, 46.4%, respectively). Women in concordant dyads had significantly higher median endocervical quantitative Ct polymerase chain reaction values (3,032) compared with CT-infected women in discordant dyads (1013 inclusion forming units DNA equivalents per mL; P < 0.01).Among 54 Ct-concordant dyads with ompA genotype data for both members, 96.2% had identical genotypes. Conclusions: Higher organism load appears associated with concordance among women. Same-genotype chlamydial concordance was high in sexual partnerships. No behavioral factors were sufficiently discriminating to guide partner services activities. Findings may help model coitusspecific transmission probabilities.

Original languageEnglish (US)
Pages (from-to)741-749
Number of pages9
JournalSexually Transmitted Diseases
Volume43
Issue number12
DOIs
StatePublished - Nov 15 2016

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Chlamydia trachomatis
Heterosexuality
Genotype
Infection
Nucleic Acids
Chlamydia Infections
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Genotype-specific concordance of chlamydia trachomatis genital infection within heterosexual partnerships. / Schillinger, Julia A.; Katz, Barry; Markowitz, Lauri E.; Braslins, Phillip G.; Shrier, Lydia A.; Madico, Guillermo; Van Der Pol, Barbara; Orr, Donald P.; Rice, Peter A.; Batteiger, Byron.

In: Sexually Transmitted Diseases, Vol. 43, No. 12, 15.11.2016, p. 741-749.

Research output: Contribution to journalArticle

Schillinger, JA, Katz, B, Markowitz, LE, Braslins, PG, Shrier, LA, Madico, G, Van Der Pol, B, Orr, DP, Rice, PA & Batteiger, B 2016, 'Genotype-specific concordance of chlamydia trachomatis genital infection within heterosexual partnerships', Sexually Transmitted Diseases, vol. 43, no. 12, pp. 741-749. https://doi.org/10.1097/OLQ.0000000000000525
Schillinger, Julia A. ; Katz, Barry ; Markowitz, Lauri E. ; Braslins, Phillip G. ; Shrier, Lydia A. ; Madico, Guillermo ; Van Der Pol, Barbara ; Orr, Donald P. ; Rice, Peter A. ; Batteiger, Byron. / Genotype-specific concordance of chlamydia trachomatis genital infection within heterosexual partnerships. In: Sexually Transmitted Diseases. 2016 ; Vol. 43, No. 12. pp. 741-749.
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abstract = "Background: Sexual transmission rates of Chlamydia trachomatis (Ct) cannot be measured directly; however, the study of concordance of Ct infection in sexual partnerships (dyads) can help to illuminate factors influencing Ct transmission. Methods: Heterosexual men and women with Ct infection and their sex partners were enrolled and partner-specific coital and behavioral data collected for the prior 30 days. Microbiological data included Ct culture, and nucleic acid amplification testing (NAAT), quantitative Ct polymerase chain reaction, and ompA genotyping. We measured Ct concordance in dyads and factors (correlates) associated with concordance. Results: One hundred twenty-one women and 125 men formed 128 dyads. Overall, 72.9{\%}ofmale partners ofNAAT-positivewomen and 68.6{\%}of female partners of NAAT-positive men were Ct-infected. Concordance was more common in dyads with culture-positive members (78.6{\%} of male partners, 77{\%} of female partners). Partners of women and men who were NAAT-positive only had lower concordance (33.3{\%}, 46.4{\%}, respectively). Women in concordant dyads had significantly higher median endocervical quantitative Ct polymerase chain reaction values (3,032) compared with CT-infected women in discordant dyads (1013 inclusion forming units DNA equivalents per mL; P < 0.01).Among 54 Ct-concordant dyads with ompA genotype data for both members, 96.2{\%} had identical genotypes. Conclusions: Higher organism load appears associated with concordance among women. Same-genotype chlamydial concordance was high in sexual partnerships. No behavioral factors were sufficiently discriminating to guide partner services activities. Findings may help model coitusspecific transmission probabilities.",
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T1 - Genotype-specific concordance of chlamydia trachomatis genital infection within heterosexual partnerships

AU - Schillinger, Julia A.

AU - Katz, Barry

AU - Markowitz, Lauri E.

AU - Braslins, Phillip G.

AU - Shrier, Lydia A.

AU - Madico, Guillermo

AU - Van Der Pol, Barbara

AU - Orr, Donald P.

AU - Rice, Peter A.

AU - Batteiger, Byron

PY - 2016/11/15

Y1 - 2016/11/15

N2 - Background: Sexual transmission rates of Chlamydia trachomatis (Ct) cannot be measured directly; however, the study of concordance of Ct infection in sexual partnerships (dyads) can help to illuminate factors influencing Ct transmission. Methods: Heterosexual men and women with Ct infection and their sex partners were enrolled and partner-specific coital and behavioral data collected for the prior 30 days. Microbiological data included Ct culture, and nucleic acid amplification testing (NAAT), quantitative Ct polymerase chain reaction, and ompA genotyping. We measured Ct concordance in dyads and factors (correlates) associated with concordance. Results: One hundred twenty-one women and 125 men formed 128 dyads. Overall, 72.9%ofmale partners ofNAAT-positivewomen and 68.6%of female partners of NAAT-positive men were Ct-infected. Concordance was more common in dyads with culture-positive members (78.6% of male partners, 77% of female partners). Partners of women and men who were NAAT-positive only had lower concordance (33.3%, 46.4%, respectively). Women in concordant dyads had significantly higher median endocervical quantitative Ct polymerase chain reaction values (3,032) compared with CT-infected women in discordant dyads (1013 inclusion forming units DNA equivalents per mL; P < 0.01).Among 54 Ct-concordant dyads with ompA genotype data for both members, 96.2% had identical genotypes. Conclusions: Higher organism load appears associated with concordance among women. Same-genotype chlamydial concordance was high in sexual partnerships. No behavioral factors were sufficiently discriminating to guide partner services activities. Findings may help model coitusspecific transmission probabilities.

AB - Background: Sexual transmission rates of Chlamydia trachomatis (Ct) cannot be measured directly; however, the study of concordance of Ct infection in sexual partnerships (dyads) can help to illuminate factors influencing Ct transmission. Methods: Heterosexual men and women with Ct infection and their sex partners were enrolled and partner-specific coital and behavioral data collected for the prior 30 days. Microbiological data included Ct culture, and nucleic acid amplification testing (NAAT), quantitative Ct polymerase chain reaction, and ompA genotyping. We measured Ct concordance in dyads and factors (correlates) associated with concordance. Results: One hundred twenty-one women and 125 men formed 128 dyads. Overall, 72.9%ofmale partners ofNAAT-positivewomen and 68.6%of female partners of NAAT-positive men were Ct-infected. Concordance was more common in dyads with culture-positive members (78.6% of male partners, 77% of female partners). Partners of women and men who were NAAT-positive only had lower concordance (33.3%, 46.4%, respectively). Women in concordant dyads had significantly higher median endocervical quantitative Ct polymerase chain reaction values (3,032) compared with CT-infected women in discordant dyads (1013 inclusion forming units DNA equivalents per mL; P < 0.01).Among 54 Ct-concordant dyads with ompA genotype data for both members, 96.2% had identical genotypes. Conclusions: Higher organism load appears associated with concordance among women. Same-genotype chlamydial concordance was high in sexual partnerships. No behavioral factors were sufficiently discriminating to guide partner services activities. Findings may help model coitusspecific transmission probabilities.

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