Germ cell origin of testicular carcinoid tumors

Phillip H. Abbosh, Shaobo Zhang, Gregory T. MacLennan, Rodolfo Montironi, Antonio Lopez-Beltran, Joseph P. Rank, Lee Ann Baldridge, Liang Cheng

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Purpose: Carcinoids are neuroendocrine tumors and most frequently occur within tissues derived fromthe embryonic gut.These tumors can occur in any organ site but are rare in the testis. The cell type giving rise to testicular carcinoid is unknown. We hypothesized that testicular carcinoid may have a germ cell origin. Experimental Design: We describe our analysis of protein and genetic markers of germ cell neoplasia, using immunohistochemistry and fluorescence in situ hybridization, in four testicular carcinoid tumors. Results: All four cases of testicular carcinoid tumor arose in a background of mature teratoma. Isochromosome 12p was identified in carcinoid tumor cells in all four samples.12p overrepresentation was also observed in three cases. Isochromosome 12p and 12p overrepresentation were present in cells of coexisting mature teratoma in three cases. Carcinoid tumors showed strong immunoreactivity for synaptophysin and chromogranin, but no immunoreactivity for OCT4, CD30, c-kit, TTF-1, and CDX2. Membranous and cytoplasmic staining for β-catenin was detected in three cases. Conclusion:Our findings suggest that testicular carcinoid represents a phenotypic expression of testicular teratoma and is of germ cell origin.

Original languageEnglish
Pages (from-to)1393-1396
Number of pages4
JournalClinical Cancer Research
Volume14
Issue number5
DOIs
StatePublished - Mar 1 2008

Fingerprint

Testicular Neoplasms
Carcinoid Tumor
Germ Cells
Isochromosomes
Teratoma
Chromogranins
Catenins
Synaptophysin
Neuroendocrine Tumors
Fluorescence In Situ Hybridization
Genetic Markers
Testis
Neoplasms
Research Design
Immunohistochemistry
Staining and Labeling

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Abbosh, P. H., Zhang, S., MacLennan, G. T., Montironi, R., Lopez-Beltran, A., Rank, J. P., ... Cheng, L. (2008). Germ cell origin of testicular carcinoid tumors. Clinical Cancer Research, 14(5), 1393-1396. https://doi.org/10.1158/1078-0432.CCR-07-4146

Germ cell origin of testicular carcinoid tumors. / Abbosh, Phillip H.; Zhang, Shaobo; MacLennan, Gregory T.; Montironi, Rodolfo; Lopez-Beltran, Antonio; Rank, Joseph P.; Baldridge, Lee Ann; Cheng, Liang.

In: Clinical Cancer Research, Vol. 14, No. 5, 01.03.2008, p. 1393-1396.

Research output: Contribution to journalArticle

Abbosh, PH, Zhang, S, MacLennan, GT, Montironi, R, Lopez-Beltran, A, Rank, JP, Baldridge, LA & Cheng, L 2008, 'Germ cell origin of testicular carcinoid tumors', Clinical Cancer Research, vol. 14, no. 5, pp. 1393-1396. https://doi.org/10.1158/1078-0432.CCR-07-4146
Abbosh PH, Zhang S, MacLennan GT, Montironi R, Lopez-Beltran A, Rank JP et al. Germ cell origin of testicular carcinoid tumors. Clinical Cancer Research. 2008 Mar 1;14(5):1393-1396. https://doi.org/10.1158/1078-0432.CCR-07-4146
Abbosh, Phillip H. ; Zhang, Shaobo ; MacLennan, Gregory T. ; Montironi, Rodolfo ; Lopez-Beltran, Antonio ; Rank, Joseph P. ; Baldridge, Lee Ann ; Cheng, Liang. / Germ cell origin of testicular carcinoid tumors. In: Clinical Cancer Research. 2008 ; Vol. 14, No. 5. pp. 1393-1396.
@article{dba1df33deb64b2e9354d856a2545aac,
title = "Germ cell origin of testicular carcinoid tumors",
abstract = "Purpose: Carcinoids are neuroendocrine tumors and most frequently occur within tissues derived fromthe embryonic gut.These tumors can occur in any organ site but are rare in the testis. The cell type giving rise to testicular carcinoid is unknown. We hypothesized that testicular carcinoid may have a germ cell origin. Experimental Design: We describe our analysis of protein and genetic markers of germ cell neoplasia, using immunohistochemistry and fluorescence in situ hybridization, in four testicular carcinoid tumors. Results: All four cases of testicular carcinoid tumor arose in a background of mature teratoma. Isochromosome 12p was identified in carcinoid tumor cells in all four samples.12p overrepresentation was also observed in three cases. Isochromosome 12p and 12p overrepresentation were present in cells of coexisting mature teratoma in three cases. Carcinoid tumors showed strong immunoreactivity for synaptophysin and chromogranin, but no immunoreactivity for OCT4, CD30, c-kit, TTF-1, and CDX2. Membranous and cytoplasmic staining for β-catenin was detected in three cases. Conclusion:Our findings suggest that testicular carcinoid represents a phenotypic expression of testicular teratoma and is of germ cell origin.",
author = "Abbosh, {Phillip H.} and Shaobo Zhang and MacLennan, {Gregory T.} and Rodolfo Montironi and Antonio Lopez-Beltran and Rank, {Joseph P.} and Baldridge, {Lee Ann} and Liang Cheng",
year = "2008",
month = "3",
day = "1",
doi = "10.1158/1078-0432.CCR-07-4146",
language = "English",
volume = "14",
pages = "1393--1396",
journal = "Clinical Cancer Research",
issn = "1078-0432",
publisher = "American Association for Cancer Research Inc.",
number = "5",

}

TY - JOUR

T1 - Germ cell origin of testicular carcinoid tumors

AU - Abbosh, Phillip H.

AU - Zhang, Shaobo

AU - MacLennan, Gregory T.

AU - Montironi, Rodolfo

AU - Lopez-Beltran, Antonio

AU - Rank, Joseph P.

AU - Baldridge, Lee Ann

AU - Cheng, Liang

PY - 2008/3/1

Y1 - 2008/3/1

N2 - Purpose: Carcinoids are neuroendocrine tumors and most frequently occur within tissues derived fromthe embryonic gut.These tumors can occur in any organ site but are rare in the testis. The cell type giving rise to testicular carcinoid is unknown. We hypothesized that testicular carcinoid may have a germ cell origin. Experimental Design: We describe our analysis of protein and genetic markers of germ cell neoplasia, using immunohistochemistry and fluorescence in situ hybridization, in four testicular carcinoid tumors. Results: All four cases of testicular carcinoid tumor arose in a background of mature teratoma. Isochromosome 12p was identified in carcinoid tumor cells in all four samples.12p overrepresentation was also observed in three cases. Isochromosome 12p and 12p overrepresentation were present in cells of coexisting mature teratoma in three cases. Carcinoid tumors showed strong immunoreactivity for synaptophysin and chromogranin, but no immunoreactivity for OCT4, CD30, c-kit, TTF-1, and CDX2. Membranous and cytoplasmic staining for β-catenin was detected in three cases. Conclusion:Our findings suggest that testicular carcinoid represents a phenotypic expression of testicular teratoma and is of germ cell origin.

AB - Purpose: Carcinoids are neuroendocrine tumors and most frequently occur within tissues derived fromthe embryonic gut.These tumors can occur in any organ site but are rare in the testis. The cell type giving rise to testicular carcinoid is unknown. We hypothesized that testicular carcinoid may have a germ cell origin. Experimental Design: We describe our analysis of protein and genetic markers of germ cell neoplasia, using immunohistochemistry and fluorescence in situ hybridization, in four testicular carcinoid tumors. Results: All four cases of testicular carcinoid tumor arose in a background of mature teratoma. Isochromosome 12p was identified in carcinoid tumor cells in all four samples.12p overrepresentation was also observed in three cases. Isochromosome 12p and 12p overrepresentation were present in cells of coexisting mature teratoma in three cases. Carcinoid tumors showed strong immunoreactivity for synaptophysin and chromogranin, but no immunoreactivity for OCT4, CD30, c-kit, TTF-1, and CDX2. Membranous and cytoplasmic staining for β-catenin was detected in three cases. Conclusion:Our findings suggest that testicular carcinoid represents a phenotypic expression of testicular teratoma and is of germ cell origin.

UR - http://www.scopus.com/inward/record.url?scp=40949093029&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40949093029&partnerID=8YFLogxK

U2 - 10.1158/1078-0432.CCR-07-4146

DO - 10.1158/1078-0432.CCR-07-4146

M3 - Article

C2 - 18316560

AN - SCOPUS:40949093029

VL - 14

SP - 1393

EP - 1396

JO - Clinical Cancer Research

JF - Clinical Cancer Research

SN - 1078-0432

IS - 5

ER -